In 1494, Christopher Columbus made a second journey to the Americas- this time with more ships, more men, and a grander mission. His goal: to build the first European colony in the New World. But in just a few short years, this settlement would perish- one fifth of its inhabitants dead, at least six ships sunk in the bay, and the legacy of Columbus permanently marred. What happened at this ill-fated settlement remains a mystery 500 years later. National Geographic joins two separate teams of archaeologists, one at sea and one on land, as they journey to uncover new evidence of the failure of America's first European city, La Isabela.