Jimmy McNulty (60 Episodes)

Cedric Daniels (60 Episodes)

Kima Greggs (60 Episodes)

Bunk Moreland (60 Episodes)

Rhonda Pearlman (60 Episodes)

Bubbles (60 Episodes)

William Rawls (60 Episodes)

Herc (35 Episodes)

Ellis Carver (35 Episodes)

Bodie Broadus (35 Episodes)

Omar Little (50 Episodes)

Ervin Burrell (50 Episodes)

Lester Freamon (37 Episodes)

Roland Pryzbylewski (25 Episodes)

Leander Sydnor (35 Episodes)

Sgt. Jay Landsman (32 Episodes)

Avon Barksdale (37 Episodes)

Stringer Bell (37 Episodes)

Tommy Carcetti (35 Episodes)

Marlo Stanfield (27 Episodes)

Chris Partlow (uncredited) (17 Episodes)

Howard "Bunny" Colvin (25 Episodes)

State Sen. R. Clayton 'Clay' Davis (16 Episodes)

D'Angelo Barksdale (25 Episodes)

Dennis "Cutty" Wise (13 Episodes)

Maurice 'Maury' Levy (24 Episodes)

Norman Wilson (23 Episodes)

Beatrice "Beadie" Russell (12 Episodes)

Malik 'Poot' Carr (18 Episodes)

Clarence Royce (13 Episodes)

Felicia 'Snoop' Pearson (17 Episodes)

Cheryl (15 Episodes)

Detective Michael 'Sanny' Santangelo (11 Episodes)

Michael Lee (14 Episodes)

Spiros "Vondas" Vondopoulos (12 Episodes)

Johnny Weeks (14 Episodes)

Roland 'Wee-Bey' Brice (14 Episodes)

Nick Sobotka (13 Episodes)

Randy Wagstaff (13 Episodes)

Judge Daniel Phelan (9 Episodes)

Off. Anthony Colicchio (13 Episodes)

Maj. Stanislaus Valchek (13 Episodes)

Frank Sobotka (12 Episodes)

Elena McNulty (12 Episodes)

Theresa D'Agostino (12 Episodes)

Wallace (12 Episodes)

Brianna Barksdale (12 Episodes)

Chester 'Ziggy' Sobotka (12 Episodes)

Melvin 'Cheese' Wagstaff (11 Episodes)

Off. Kenneth Dozerman (11 Episodes)

Sergei 'Serge' Malatov (11 Episodes)

Thomas 'Horseface' Pakusa (11 Episodes)

Council President Nerese Campbell (11 Episodes)

Augustus Haynes (10 Episodes)

Scott Templeton (10 Episodes)

Michael Steintorf (10 Episodes)

Duquan "Dukie" Weems (10 Episodes)

Alma Gutierrez (10 Episodes)

Shardene Innes (10 Episodes)

Marla Daniels (9 Episodes)

Joseph 'Proposition Joe' Stewart (9 Episodes)

Maj. Raymond Foerster (6 Episodes)

Nathaniel 'Nat' Coxson (9 Episodes)

Dante (8 Episodes)

Renaldo (8 Episodes)

The Greek (8 Episodes)

Wendell 'Orlando' Blocker (7 Episodes)

Executive Editor James C. Whiting III (7 Episodes)

FBI Spec. Agent Terrance 'Fitz' Fitzhugh (7 Episodes)

Anton 'Stinkum' Artis (7 Episodes)

Lt. Charles Marimow (6 Episodes)

Ghost (uncredited) (6 Episodes)

Aimee (6 Episodes)

Fruit (5 Episodes)

Eton Ben-Eleazer (5 Episodes)

Det. Augustus Polk (5 Episodes)

Dr. Randall Frazier (5 Episodes)

George 'Double G' Glekas (5 Episodes)

Maui (5 Episodes)

Asst. State's Atty. Ilene Nathan (5 Episodes)

Lt. Dennis Mello (5 Episodes)

Slim Charles (5 Episodes)

Damien 'Day-Day' Price (4 Episodes)

Roger Twigg (4 Episodes)

Maj. Bobby Reed (4 Episodes)

Louis Sobotka (4 Episodes)

Brother Mouzone (4 Episodes)

(3 Episodes)

(3 Episodes)

Marvin (uncredited) (3 Episodes)

Arabber (als Reggie A. Green) (3 Episodes)

Det. Patrick Mahon (3 Episodes)

Savino Bratton (3 Episodes)

Butchie (3 Episodes)

Agent Kristos Koutris (3 Episodes)

Off. Oscar Requer (2 Episodes)

Roman (2 Episodes)

Comstat Police Major (uncredited) (2 Episodes)

(2 Episodes)

Marquis 'Bird' Hilton (2 Episodes)

Shaun Williams (2 Episodes)

Special Agent Kleary (1 Episodes)

Walon (2 Episodes)

Wintell 'Little Man' Royce (2 Episodes)

Joan Sobotka (2 Episodes)

Bruce DiBiago (2 Episodes)

John 'Johnny Fifty' Spamanto (2 Episodes)

Off. Caroline Massey (2 Episodes)

Tosha Mitchell (2 Episodes)

Bodie's Grandmother (2 Episodes)

Ilona Petrovich (uncredited) (1 Episodes)

Off. Karen (as Mary Beth Wise) (2 Episodes)

Prissy (1 Episodes)

Crackhead (uncredited) (1 Episodes)

Former Mayor 'Young Tony' (1 Episodes)

(1 Episodes)

(1 Episodes)

John Munch (1 Episodes)

Pretty Lesbian (uncredited) (1 Episodes)

Security Supervisor (uncredited) (1 Episodes)

(1 Episodes)

Desk Sergeant (uncredited) (1 Episodes)

Performer/Vocalist (1 Episodes)

Det. Ray Cole (uncredited) (1 Episodes)

Zenobia Dawson (1 Episodes)

Car Theft Reporting Lt. (uncredited) (1 Episodes)

William Gant (1 Episodes)

Asst. State's Atty. Taryn Hanson (1 Episodes)

Det. Frank Barlow (1 Episodes)

Lt. Walter Cantrell (1 Episodes)

State Police Undercover Troy Wiggins (1 Episodes)

'Ronnie Mo' Watkins (1 Episodes)

CO Dwight Tilghman (1 Episodes)

Michael 'White Mike' McArdle (1 Episodes)

FBI Supervisor Amanda Reese (1 Episodes)

Brandon Wright (1 Episodes)

Michael McNulty (1 Episodes)

Det. Edward Norris (1 Episodes)

Sean McNulty (1 Episodes)

Det. Vernon Holley (1 Episodes)

Hucklebuck (1 Episodes)

FBI Spec. Agent Arnold D. Paulette (1 Episodes)