Longtime friends and Hollywood icons, Jane Fonda and Lily Tomlin tell Dr. Agus their secrets to longevity and aging gracefully. From the foods that keep them young, to intimacy in their 80s and the benefits of cannabis on a good night's sleep, there is no topic that's off limits.

TV host, comedian, rapper, Nick Cannon reveals the story of his near-fatal Lupus diagnosis and the crushing loss of his infant son, Zen to a malignant brain tumor. In an intimate conversation with Dr. Agus, Nick opens up about how these heartbreaking, life changing events have become his greatest lessons.

Amy Schumer opens up about her fertility issues, near 30-year battle with consistent pain, and childhood of trauma filled with mental health struggles.

Howie Mandel is joined by his oldest daughter Jackelyn to discuss how their mutual battles with obsessive-compulsive disorder impact their lives.

Oprah Winfrey and Maria Shriver talk about women's health, specifically a misunderstood and often mistreated issue: menopause.

Ashton Kutcher shares his terrifying battle with a rare and life-threatening disease and sits down for his first interview with his twin brother, Michael.