Five people with an odd connection go missing from a coffee shop, and the team determines what the connection had to do with their disappearance. Meanwhile, Samantha gets ready for the birth of her child.
A truck driver goes missing after saving a boy's life, and the team determines if that has anything to do with his disappearance. Meanwhile, Jack's mental health is examined by a psychiatrist.
After the latest lottery winner goes missing, the team works to figure out why.
The team searches for a coma patient who had woken up after three years only to disappear.
While struggling to deal with the aftermath of Jack's accident, the team searches to find a teen heart transplant recipient, believing her disappearance might be connected to her donor. Samantha talks to Brian.
Jack goes missing after taking a case into his own hands which soon becomes intertwined with a human trafficking prostitution case that Vivian is working on.
The team work on a case where a veterans-hospital worker vanishes and have two leads.
Malone and his team start off the new year investigating how a private investigator might have went missing.
A child prodigy turned store Santa vanishes and the team wonders if he had criminal connections.
The team determines if an ex-con's past criminal activity caused her to disappear after visiting a prison inmate. Det. Mars and Agent Johnson also continue their investigation.
The disappearance of an ultimate fighter leads the team to investigate his background, where they learn the man had a number of enemies.
When a college student disappears after making racial remarks in a class, the team wonders if those may be directly connected to his disappearance.
Malone's team joins forces with Gil Grissom, a CSI from Las Vegas, and his team as they track a serial killer with ties to New York. The crossover starts on CSI: Crime Scene Investigation S08E06 Who and What (I).
An office shooting forces a woman to disappear, possibly to hide a deep secret.
When a woman disappears after her boyfriend is killed by the police, the team suspects gang involvement. Later, Sam learns she's pregnant.
The team searches for a missing mother who they believe may be searching for her son, who is also missing.
The team considers if a father who cleans crime scenes for a living led to his disappearance with his daughter.
The four-year-old adopted son of a celebrity couple is kidnapped, and the team must determine if the reason has to deal with the parents' status or the boy's own Sudanese origin.
