In season three, the Gecko brothers find themselves in the vortex of the Culebra world, thrust into a fight against the forces of hell. The Geckos assemble an unlikely crew to take on the new enemies determined to take them down.

In season two, core relationships deepen and become more complicated as everyone tries to put their lives back on track after one very insane day. Santánico and Richie (living outside of Houston) are now partners in crime, resembling a more modern version of Bonnie and Clyde; Seth and Kate are scraping by as small time criminals south of the border; and Freddie Gonzalez has an almost obsessive focus on protecting his wife and young daughter in the suburbs. Carlos Madrigal and Scott Fuller emerge from the Titty Twister, changed men. They will all come together once again – this time facing off against an even bigger threat.

The Gecko brothers are wanted by the authorities after a bank heist leaves several dead. Escaping to mexico, chaos ensues when they take hostages and detour to a strip club that is populated by vampires.