Anaïs Davis is the central character, and the season focuses on her burgeoning romantic relationship with Bobbie. Themes of this season include alcohol abuse, substance abuse, divorce, reckless behavior, and friendship.

This season shifts to the perspective of a new class of students at Kunstkaai Secondary School, a school that focuses on artistic and creative pursuits. The central character is Ada Konings, who attempts to understand her sexuality as she hesitates to lose her virginity to her boyfriend, Finn. The season also follows her friendships and relationships with Hanne, Otis, Anaïs, Noah, and her older half-sister, Mila, who was held back a year in school.

Yasmina Ait Omar is the central character, with the season focusing on ideas of faith and religion, being Muslim in Belgium, and the holy month of Ramadan.

The series diverged from the original SKAM storyline with a new character, Kato Fransen. The storyline deals with social media, racism, self-harm, drugs, and COVID-19.

Robbe IJzermans is the central character and the season focuses on his coming out as gay and his relationship with Sander, who struggles with bipolar disorder. It also deals with themes of sexual identity, homosexuality, and mental health.

Zoë Loockx is the central character and the season focuses on her relationship with Senne, a popular boy at school, and themes of friendship, self-image, and sexual abuse.

Jana Ackermans is the central character and the season focuses on her relationship with her boyfriend Jens as well as themes of loneliness, identity, and friendship.

A series of clips that aired during the first COVID-19 lockdown in Belgium (wtFOCKDOWN). The clips feature video calls between the characters that take place between seasons 3 and 4.