In the final hours of python season, hunters launch a full assault to win the battle against the vicious invaders. With the clock ticking to save the Everglades, teams race back to old honey holes to track down the most elusive beasts, while Dusty bids farewell to his longtime partner.

Troy and Tes discover a new hot spot. Zak and Aaron encounter unexpected company. Ashley and Kaylyn hunt the notorious Camel Hump. Dusty trains the next generation of hunting dog.

As a heatwave scorches the Everglades, Troy and Tes intercept pythons charging toward the rivers. Zak and Aaron venture far west to a remote canal. Ashley and Kaylyn gamble on an all-night hunt. Dusty scavenges for his next meal.

Troy and Tes venture into gator territory. Zak and Aaron chase a hog-eating monster. Ashley and Kaylyn hunt the edges of a wildfire. Dusty launches a new business venture.

Zak and Aaron make a bet with Ashley and Kaylyn to reignite their seasons. Troy and Tes voyage to the cypress strand in the middle of the Glades. Dusty puts his swamp bartering skills to the ultimate test.

Troy and Tes gamble on new hunting grounds; Ashley and Kaylyn follow an old surveyor's trail; Zak and Aaron place their bets on Bad Luck Prairie; Dusty resurrects an old boat to reach distant honey holes.

Troy and Tes hunt for a horse-killing gator. Zak and Aaron gamble on the Dead Sea. Ashley and Kaylyn explore a distant honey hole. Dusty launches a new scheme.

Zak and Aaron combat an invasion in Zak's neighborhood. Tes works alone in the depths of buggy country. Ashley and Kaylyn hunt near a camp with a haunting past. Dusty chases an old nemesis.

Troy and Tes hunt in the wake of a prescribed burn. Zak and Bruce try to break a cold streak on Bruce's last day in the Everglades. Dusty confronts an enemy invader. Ashley and Kaylyn hit an unexpected dead end.

Ashley and Kaylyn enlist the help of a blind hunting dog. Dusty bets his fortunes on Python Palace. Troy and Tes investigate rumors of an old camp infested with pythons. Hunting solo, Zak struggles to penetrate a cypress forest.

Troy and Tes search for a beast terrorizing a local camp. Ashley and Kaylyn hunt in the wake of Hurricane Ian's destruction. Zak and Bruce return to Monster Highway. Dusty launches a new business venture.

As the Everglades suffer a sudden dry spell, Troy and Tes gamble on a voyage to the glades' tree islands. Ashley and Kaylyn hunt along a river full of gators. Zak and Bruce sweat it out on a kayak mission down the canals.

Troy and Tes chase a legendary monster; Dusty changes plans on the fly to save a friend; Zack and Bruce bet big on logging country; Ashley and Kaylyn break into a jungle in search of a python honey hole.

Ashley and Kaylyn charge onto Bear Ridge; Zak and Bruce answer an urgent call for help; Troy and Tes go into battle to defend a bird sanctuary; Dusty puts on his inventor hat to save the Glades.

Troy and Tes race a mounting storm. Zak and Bruce battle an invasion of deer-eating beasts. Ashley and Kaylyn search for a legendary monster. Dusty hatches a daring plan to strike it rich.

Hunters return to the Everglades to find the enemy transformed. Giant female pythons have learned to hide from their pursuers, allowing them to breed faster than ever. Now the swampers must dive deep into their secret lairs and remove the beasts before the glades are lost forever.