Jesse finds Cyrus Duke's treasure map and meets up with Bo, Luke and Daisy in the Phillippines to find it. They are going to turn in the $20 million so they can get the reward and pay off the mortgage. Unfortunately, the Dukes are going to have to outmaneuver Boss and a crook named Richards, who are after the treasure for themselves.
Boss has a crook named Geraldo run the Dukes off the road. They are helped out by a boy named Pepino and his racehorse, El Blanco. Pepino is racing the next day to save his grandfather's ranch. Geraldo wants his horse, El Diablo, to win so he has Boss steal El Blanco. The Dukes have to find the horse, win at the track and get back in the race.