Ash deals with his daughter's admission to the ED after being hit by a drunken police driver, while Tom's judgement is called into question when a baby he has discharged nearly dies.
Zoe goes out of her way to help and protect a young girl who she believes is at risk of female genital mutilation. Fletch deals with a man who needs to take responsibility for his health and lifestyle.
Ash and Zoe struggle to make a teenage boy accept the severity of his father's condition, while Linda helps a pregnant woman cope with her waster boyfriend.
Big Mac thinks he may have finally found the woman of his dreams but when she mistakes him for a doctor he doesn't set her straight. Ash clashes with Zoe when he carries out a risky procedure without telling her.
Jeff must persuade David to act in his son's best interests, Fletch is determined to help an elderly man in love, and Zoe returns from sick leave and clashes with Ash.
David tracks down his estranged wife, Kate, to get her help in saving their 10-year-old son who is dying of leukaemia. Meanwhile, Zoe has had to go home sick, leaving Ash to deal with the continuing flu epidemic.
New doctor Ash hits the ground running when he treats a patient with suspected rabies, and Aoife is forced to take control when ex-boyfriend Craig arrives in Holby.
Jordan fights to keep his girlfriend's life support machine switched on but when an ill young woman arrives in the ED, he's forced to reconsider his motives.
Tensions once again rise between Tom and Dominic as they argue over the treatment of a baby with severe hypothermia, and Dylan finally admits that he has not moved on from Sam.
Tamzin's decision not to treat an aggressive patient has serious repercussions, and Tom and Sam differ over how to approach a family with a dark secret.
Zoe oversteps the line when she attempts to help a vulnerable young woman, and Mac gets into serious trouble on his first day back when a patient with Alzheimer's appears to have swallowed some cleaning fluid.
Medical drama. Fletch plays a practical joke on Lloyd after a staff night out, and Dylan attempts to teach a medical student about the dangers of alcohol abuse.
The team is put to the test when Holby is hit by severe weather, and the stress of work and dealing with a face from the past leads Big Mac's health to take a dangerous turn.
Sam and Tom are pushed to their limits when a female cage fighter insists on fighting against their advice, and a wedding is threatened to be ruined by devastating news.
Tamsin faces a ghost from her past when she and Jeff attend a call out at a lap dancing club. Sam attempts to unravel the mystery of a patient with amnesia.
Zoe's first day as the ED'S clinical lead gets off to a trying start when the team are faced with dealing with the aftermath of a tunnel collapse at a music festival.