When a mysterious stranger summons Malory and her intrepid ISIS agents to Monaco, all bets are off! Well, actually all bets are on. Because Monaco is basically one giant casino, and Archer has $4 million in untraceable bearer bonds. Also, it's Gran Prix week, so you can just forget getting a hotel room
When Archer discovers that the chemotherapy drugs he has been taking are phony, he goes on a rampage against the Irish gangsters behind the scheme. He also makes friends with a fellow marijuana-toking cancer patient (voice of Joan Van Ark). Meanwhile, Cyril learns why Krieger is fluent in Portuguese.
Archer and Lana head to Louisiana to stop an ecoterrorist from blowing up a natural-gas pipeline. (Archer’s also looking forward to a Big Easy vacation.) Back at ISIS headquarters, Mallory orders the staff to go green to get “freebie socialist tax credits.” A flashback recalls Lana’s introduction to ISIS.
After Malory is wiped out in a Ponzi scheme, she hatches a scheme of her own: selling ISIS - lock, stock and snack machines - to archrival spy agency ODIN. Archer and the rest of the ISIS employees, rightfully fearing for their jobs, must use every trick in the book (ISIS Field Manual, 3rd Edition) to try to stop the sale.
In yet another attempt to secure funding for ISIS, Malory drags her agents to the luxury winter resort town of Gstaad to protect a Swiss billionaire's daughter from a kidnapping threat. But Archer soon finds out the real threat is his protectee: an underage nymphomaniac who will stop at nothing to bed the world’s greatest spy.