After leaving a friend's hotel, 17-year-old Brittanee Drexel suddenly disappears during spring break in Myrtle Beach; the case comes alive when twisted and disturbing details start to emerge from a prison cell.

6-year-old Timmothy Pitzen vanishes after a three-day trip to waterparks and the zoo with his mom. In a terrifying twist, his mom is found dead in a motel room with a disturbing note by her side.

In 2011, baby Lisa Irwin goes missing from her crib in the middle of the night and is never found. Stolen cell phones and a disturbing charge on a parent's debit card adds to the mystery.

Three young brothers are reported missing the day after Thanksgiving in 2010. In a shocking twist, their daddy claims he gave them to an underground group -- but investigators say his story doesn't add up.

After 7-year-old Kyron Horman's stepmother drops him off at a school science fair and takes a picture, the little boy is never seen again; his disappearance is one of the largest mysteries and investigations in Oregon's history.

Russell Dermond's headless body is discovered in the garage of his million-dollar lakefront mansion; his wife, shirley, is found floating dead in the water, her ankles tethered with cinder blocks. One key piece of evidence remains missing.