A raging fire kills Nanette Krentel in her secluded home in the middle of the day. Investigators are puzzled why she was unable to escape, until the autopsy reveals the cause of death was a gunshot wound to the head.

College student Faith Hedgepeth is found bludgeoned to death in an off-campus apartment in Chapel Hill. DNA, a threatening note at the crime scene, and a voicemail from Faith’s cellphone could point to her killer.

Mother of five, Jennifer Dulos, disappears after dropping her kids at school, but evidence shows a brutal assault in the garage of her upscale, Connecticut home.

Avid outdoorsman Kenny Veach vanishes near the mysterious Area 51. Searchers find his cell phone near a mine shaft, but no sign of Kenny. In earlier, recorded video, Veach describes his body vibrating as he approaches a cave near the same location.

Brian Shaffer, a handsome, young medical student, is out celebrating the start of Spring Break with friends after cramming for medical exams. Brian is clearly recorded on surveillance video entering a bar, but is mysteriously never seen leaving.

35-year-old Crystal Rogers, a mother of five, goes missing and her car is found on the side of the Bluegrass Parkway with a flat tire and her keys, purse, and cell phone all left inside. But Rogers’ disappearance isn’t the only mystery casting a shadow over Bardstown, Kentucky.