Flo Rida is here with his new album Only 1 Flo and hopefully some explanation for the state of Florida. Comedian Jo Koy, comedian Sarah Colonna and comedian Mo Mandel
One of the greatest gifts television has ever given us, John Stamos who's been guesting on Glee is here. Comedian Josh Wolf, comedian Heather McDonald and TV personality Ross Mathews
Animal expert Donald Schultz is here with an alligator, a prairie dog and a rattlesnake. Comedian Bobby Lee, comedian Whitney Cummings and TV personality Ross Mathews
Taylor Swift has a new album, called Speak Now, and she's here to tell us all about it. Topless comedian Brad Wollack, comedian Loni Love and comedian Gary Valentine
It's the return of Single Staffers...just in time for the holiday season, you're welcome America! Comedian John Caparulo, actress-Comedian Arden Myrin and comedian Ryan Stout.
Nelly is dropping by with his new album 5.0. This is for real, this is not just a dream...nailed it. Comedian Chris Franjola, E! News correspondent Michael Yo and TV personality Ross Mathews
Dancing With the Stars' extraordinary host and Deb's BFF (sorry, Gary) Tom Bergeron is here. Comedian Dan Levy, comedian Sarah Colonna and comedian Gary Valentine
Trey Songz is bringing his Passion Pain and Pleasure (also the name of his new CD) to the show tonight, word. Comedian Jo Koy, comedian Heather McDonald and comedian T.J. Miller
Florence Welch, from one of this year's hottest acts, Florence + the Machine, is here. Comedian Jim Norton, comedian Brad Wollack and actress-comedian Arden Myrin
Find out how all of the stars align tonight with cosmic astrologists Starsky and Cox. Comedian Loni Love, comedian John Caparulo and TV personality Ross Mathews
Kendra Wilkinson-Baskett is here to tell us all about the new season of her show Kendra. Comedian Jo Koy, comedian Matt Braunger and comedian Chris Hardwick
We've got YouTube sensation Keenan Cahill debuting his brand new video on the show tonight. Comedian Josh Wolf, comedian Chris Franjola and comedian Sarah Colonna
From dare I say the greatest television show of all time (Friday Night Lights), we welcome Tami Taylor herself, the Emmy-nominated Connie Britton. Writer Diablo Cody, comedian Guy Branum and TV personality Ross Mathews.
Benji and Joel Madden are here to tell us all about Good Charlotte's new album Cardiology. Comedian Josh Wolf, comedian Heather McDonald and comedian Bill Bellamy.
Jennifer Nettles of Sugarland returns tonight with their new album The Incredible Machine. Comedian John Caparulo, comedian Sarah Colonna and comedian Chris Hardwick.
The newest member of the Grand Ole Opry, Blake Shelton is here with his new album All About Tonight. Comedian Jo Koy, comedian Heather McDonald and E!'s own Michael Yo.
From Private Practice, the delightful Amy Brenneman returns to the show tonight. Comedian Chris Franjola, actress-comedian Arden Myrin and comedian Kevin Hart.
Author of Sugar and Spice and Lauren Conrad Style the very busy Lauren Conrad is here. Comedian John Caparulo, comedian Josh Wolf and comedian Jim Breuer.
The cowboy himself, Trace Adkins, is back with his new album Cowboy's Back in Town. Comedian Brad Wollack, comedian Chris Hardwick and comedian Natasha Leggero.
Tommy Lee is here with his latest Methods of Mayhem project A Public Disservice Announcement. TV personality Ross Mathews, comedian Whitney Cummings and comedian Guy Branum.
Parenthood's Dax Shepard is here to discuss many a things, one being his new film The Freebie. Comedian Chris Franjola, comedian Dan Levy and TV personality Ross Mathews.
From the hilarious movie You Again, Jersey Shore's No. 1 fan Kristen Bell is here. Comedian Bobby Lee, comedian Whitney Cummings and TV personality Ross Mathews.
Usher has a new album, Versus, is on tour and is hanging out with us tonight, everyone rejoice. Comedian Loni Love, comedian Chris Franjola and musician Jeff Wild.
VMA performer and five-time nominee B.o.B is here with his No. 1 album B.o.B Presents: The Adventures of Bobby Ray. Comedian Matt Braunger, comedian Heather McDonald and comedian Josh Wolf.
Mel B. tells us about her new Style Network show Mel B: It's a Scary Life. Comedian Greg Proops, actress-comedian Arden Myrin and comedian-host Rove McManus.
You asked for more round table, tonight you're getting more round table. You're welcome, America. Comedian Chris Franjola, comedian Loni Love and comedian Joe DeRosa
Jerry Springer tells us about his foray into game shows as host of GSN's Baggage. Comedian Randy Sklar, comedian Christina Pazsitzky and comedian Guy Branum.
Rufus Wainwright tells us about his tour and latest CD, All Days are Nights: Songs for Lulu. Comedian Josh Wolf, comedian Heather McDonald and musician Jeff Wild.
From the most frightening 3D movie of the summer, Piranha: 3D, Elisabeth Shue is here. Comedian Chris Franjola, comedian Owen Benjamin and comedian Jo Koy
Kim and Kourtney Kardashian are here to make sure everyone is still Keeping Up With the Kardashians. Comedian Bill Bellamy, comedian Natasha Leggero and comedian Josh Wolf.
Grey's Anatomy star Kim Raver tells us about her foray into the Lifetime TV movie, Bond of Silence. Comedian Finesse Mitchell, actress-comedian Arden Myrin, and TV personality Ross Mathews
We're checking in with Alanis Morissette who's working her acting chops on the new season of Weeds. Comedian Bobby Lee, comedian Loni Love and comedian Dov Davidoff.
Margaret Cho tells us about her new comedy/music album Cho Dependent. Comedian Heather McDonald, comedian Hyla Mathews and TV personality Ross Mathews.
Comedian Kathy Griffin on her show, "Kathy Griffin: My Life on the D-List"; Round table discussion with comics Jo Koy, Michael Yo, and Whitney Cummings.
Dust off your fists, girls, because Arsenio Hall is in the house. Comedian Chris Franjola, comedian Christina Pazsitzky and TV personality Ross Mathews
Canadian animal trainer Dave Salmoni on his new show, "Savaged with Dave Salmoni"; Round table discussion with comics Jason Sklar, Natasha Leggero, and Gary Valentine.
Kristin Cavallari is here and has all the info you're dying to know about the final season of The Hills. Comedian Chris Hardwick, comedian Heather McDonald and comedian Dov Davidoff
Pharrell does a lot, like producing the soundtrack and composing the score for Despicable Me. Comedian Jo Koy, comedian Whitney Cummings and TV personality Ross Mathews.
From the most-anticipated movie in the country, Eclipse, Bryce Dallas Howard is here. Comedian Brad Wollack, comedian John Caparulo and comedian Christina Pazsitzky
Comedian Matt Braunger, comedian Moshe Kasher and comedian Guy Branum. Lakers champ Ron Artest tries to get into Chelsea's pants and chats about his NBA win. Plus, hear about his budding music career!
Learn about the borderline amazing new As Seen on TV Products with A.J. Khubani. Comedian Chris Franjola, comedian Whitney Cummings and comedian Finesse Mitchell.
We're getting a little Lilith tonight when Sarah McLachlan stops by and talks her new album, Laws of Illusion. Comedian Jo Koy, E!'s own Michael Yo and comedian Sarah Colonna.
True Blood is returning and Stephen Moyer is here, so get excited...or scared?! I'm not really sure. Comedian Jo Koy, comedian Eric Price and comedian Chris Franjola.
Dancing With the Stars' hottest couple Erin Andrews and Maksim Chmerkovskiy. Comedian John Caparulo, comedian Heather McDonald and comedian Donnell Rawlings.
From the highly anticipated movie Date Night, the Academy Award-nominated Taraji P. Henson is here. Comedian Chris Franjola, comedian Chris Hardwick, TV personality Ross Mathews.
Things get real philanthropic up in here with Tom's Shoes founder Blake Mycoskie. Comedian Greg Behrendt, comedian Jen Kirkman and comedian Matt Braunger.
Find out how spunky Chelsea can really be when TV Icon and star of Up Ed Asner stops by. Comedian Josh Wolf, comedian Loni Love and comedian Wil Anderson.
Chuy Bravo wrote a book, Little Nuggets of Wisdom, and he's here to share them. This, BTW, is all 100 percent for real, for real, girl. Comedian Heather McDonald, comedians Randy & Jason Sklar.
Ludacris is back with his new album Battle of the Sexes and this time he's bringing drinks. Comedian Ben Gleib, comedian Natasha Leggero and comedian Guy Branum.
We're so thrilled to welcome the author of Where Mercy Is Shown, Mercy Is Given, Dog the Bounty Hunter. Comedian John Caparulo, comedian Heather McDonald and TV personality Ross Mathews.
We catch up with Avril Lavigne, who sings "Alice," the title song from Tim Burton's Alice in Wonderland. Comedian Sarah Colonna, comedian/TV host Rove McManus and comedian Mo Mandel.
From the highly anticipated Diary of a Wimpy Kid, the purely entertaining Rachael Harris is here. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.
Alexis Neiers, Gabrielle Neiers and Tess Taylor are here from their aptly titled new series on E! Pretty Wild. Comedian Brad Wollack, comedian Dan Levy and comedian Josh Wolf.
Someone got some time away from the O.R., Grey's Anatomy's Kevin McKidd is here. Comedian John Caparulo, comedian Arden Myrin and comedian Chris Franjola.
Kendra and Hank Baskett are here to tell us all about the spellbinding new season of Kendra. E!'s own Michael Yo, comedian Sarah Colonna and comedian Jo Koy.
Things might get wild with Radha Mitchell star of the new thrilling horror movie The Crazies. Comedian John Caparulo, comedian Bill Bellamy and actress-comedian Arden Myrin.
We're pretty thrilled that Danica Patrick makes a pit stop over at Chelsea Lately today. Comedian Josh Wolf, comedian Whitney Cummings and comedian Jo Koy.
House of Payne's Keshia Knight Pulliam is one hard working lady; Dr. Huxtable would be so proud. Comedian Loni Love, TV personality Rove McManus and comedian Michelle Collins
Lisa Edelstein from House is back again...Wait, so who's running Princeton Plainsboro? Comedian Josh Wolf, comedian Heather McDonald and comedian Ryan Stout.
Things get really scandalous when author Jackie Collins stops by with her new book, Poor Little Bitch Girl. Comedian Chris Hardwick, comedian Jen Kirkman and comedian Jo Koy.
We're beyond pleased to welcome back our animal guy Dave Salmoni and his new animal friends. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Mo Mandel.
James Van Der Beek is in the new movie Formosa Betrayed and popping up all over TV—even here! E!'s own Michael Yo, comedian Sarah Colonna and comedian Guy Branum.
Who wouldn't be stoked that Kaley Cuoco from the megapopular Big Bang Theory is here? Comedian Heather McDonald, TV personality Ross Mathews and comedian Lavell Crawford.
Clear eyes, full hearts, can't lose with Legion's Adrianne Palicki (aka FNL's Tyra). Comedian Chris Hardwick, actress-comedian Arden Myrin and comedian Eric Price.
David Arquette is back and telling us all about his new play The Female of the Species and the Golden Globes! Comedians Michelle Collins and Randy and Jason Sklar
Fist pumps all around for Jersey Shore's Snooki, Pauly D and The Situation. Comedian Chris Franjola, comedian Whitney Cummings and TV personality Ross Mathews.
Word on the street is Giuliana and Bill Rancic are trying to have a baby. What're the odds that we'll get any sort of big announcement? Comedian Brad Wollack, comedian Natasha Leggero and comedian Matt Braunger.
Holly Madison is dropping on by her old E! family today...we've missed her, too. Comedian Donnel Rawlings, comedian Heather McDonald and comedian Gary Valentine.
We're starting off the new year with Robin Thicke and his Sex Therapy...like father like son. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Guy Branum are on the panel.