In her opening monologue, host Chelsea Handler talks about what she did today at the studio on this the last day of the show, including the last communal shower she had in the Chelsea Lately shower facility. Chelsea and Chuy bring on her current stable of round table regulars. What Chelsea believes is going to be three of her closest celebrity friends, Mary McCormack - her best friend - Jennifer Aniston, and Sandra Bullock, providing a gracious send-off ends up being what they hope will be more useful for Chelsea's life. Chelsea's ex-lover 50 Cent and G-Unit perform their new single, "Watch Me". Chuy, via a prepared video, talks about what this show and Chelsea have meant to him. Miley Cyrus, in tribute to it being the last show, performs the pop classic, "It's Over". And many of Chelsea's musical friends, and some non-musical friends, help her serenade E!, to who she is grateful for the past seven years.

Liv Tyler ("The Leftovers") is interviewed.

Megan Fox is interviewed.

NBA player Chandler Parsons.

Ethan Hawke is interviewed.

Country music artist Jake Owen is on the guest list.

We don't have an overview translated in English.

Chris Pratt is interviewed.

Kelsey Grammer is interviewed.

John C. Reilly is interviewed.

We don't have an overview translated in English.

Natasha Lyonne and Uzo Aduba, stars of "Orange Is the New Black," are interviewed.

Frank Grillo, star of "The Purge: Anarchy," is interviewed.

Lela Loren is interviewed.

Dean Norris ("Under the Dome") is interviewed.

Cameron Diaz is interviewed. On the panel: Mary McCormack; Whitney Cummings; Julian McCullough.

Dane Cook is on the guest list. On the panel: Ben Gleib; Bobby Lee; Ross Mathews.

Model Chrissy Teigen is interviewed. On the panel: Josh Wolf; Loni Love; Gary Valentine.

Bel Falcone is interviewed.

Susan Sarandon is interviewed. On the panel: Chris Franjola; Arden Myrin; Kurt Braunohler.

Melissa McCarthy is interviewed. On the panel: Jeff Wild; Loni Love; Brad Wollack.

Eric Bana is interviewed about his starring role in the thriller "Deliver Us From Evil."

Chris Rock is interviewed. On the panel: Brody Stevens; April Richardson; and Jo Koy.

Comedian Gabriel Iglesias is on the guest list.

Jenna Dewan-Tatum chats about Season 2 of her Lifetime drama "Witches of East End."

Kevin Hart is interviewed.

Meagan Good appears in support of her movie "Think Like a Man Too." Also: Ben Gleib, Fortune Feimster and Ryan Stout are on the panel.

Laverne Cox ("Orange Is the New Black"). On the panel: Chris Franjola; Michael Yo; Josh Wolf.

The cast of the Lifetime reality series "Little Women: LA" are on the guest list. Panelists include Greg Fitzsimmons, Sarah Tiana and Julian McCullough.

Jason Biggs ("Orange Is the New Black") is interviewed.

Rob Riggle is interviewed. On the panel: Moshe Kasher; Fortune Feimster; and Bobby Lee.

Jenny Slate chats about her movie "Obvious Child." On the panel: Liza Treyger; Jen Kirkman; Julian McCullough.

Chelsea chats with Channing Tatum.

Lena Headey is interviewed.

Colin Hanks is interviewed.

Singer Austin Mahone is interviewed.

Giovanni Ribisi is interviewed. On the panel: Jeff Wild, Natasha Leggero and Josh Wolf.

Kelly Osbourne is on the guest list.

Lea Michele is interviewed.

Sarah Silverman.

Terry Crews is interviewed.

Joel McHale is interviewed.

Drew Barrymore and Adam Sandler are interviewed.

Charlize Theron is interviewed.

Australian rapper Iggy Azalea is interviewed. On the panel: Michael Yo; Bobby Lee; and Jo Koy.

Evan Peters is on the guest list. On the panel: Ron Funches, Sarah Tiana and Brad Wollack.

"Nurse Jackie" star Edie Falco is on the guest list.

Jason Priestley chats about his memoir.

Sandra Oh is interviewed.

Connie Britton is interviewed.

Dave Franco is interviewed. On the panel: Nick Thune; Ian Karmel; Heather McDonald.

Arianna Huffington is interviewed. On the panel: Jen Kirkman; Kevin Christy; and Josh Wolf.

Jane Lynch is interviewed. On the panel: Chris Franjola; April Richardson; Gary Valentine.

Rapper 2 Chainz is interviewed. On the panel: Julian McCullough; Brad Wollack; and Liz Carey.

Neon Trees' frontman Tyler Glenn is interviewed.

Helen Hunt discusses her role in the film "Decoding Annie Parker."

Hugh Dancy ("Hannibal") is on the guest list.

Giuliana and Bill Rancic are interviewed.

Guest host Mary McCormack

Guest hosts Loni Love

Guest host T.J. Miller

Guest host Khloe Kardashian

Brooklyn Decker is interviewed. On the panel: Michael Yo; Loni Love; and Matt Braunger.

Singer-songwriter Ellie Goulding is interviewed. On the panel: Bobby Lee; Whitney Cummings; and Julian McCullough.

Marlon Wayans is interviewed.

Comedian Amy Schumer is interviewed. On the panel: April Richardson; Sarah Colonna; and Ross Mathews.

Nikolaj Coster-Waldau is interviewed.

Sebastian Stan chats about his role in "Captain America: The Winter Soldier." On the panel: Kerri Kenney-Silver; Dustin Ybarra; and Heather McDonald.

Jamie Foxx is interviewed. Also: John Caparulo, Beth Stelling and Brad Wollack appear on the panel.

Mindy Kaling is interviewed.

Don Cheadle is interviewed.

Mark Cuban is interviewed.

Demián Bichir.

Bradley Trevor Greive stops by with cute baby animals.

Rapper Rick Ross is interviewed.

Jayma Mays is interviewed.

Drew Brees is interviewed.

Johnny Weir and his husband split up, Selfies are causing a rise in plastic surgery, Is Malaysian Flight 370 somewhere off the coast of Australia, and snowboard champion Shaun White is here.

George Clooney has a new girlfriend, John Mayor is sueing Charlie Sheen's friend, The Duke porn star is getting rich, and from "Enlisted" Geoff Stults is here.

The Pope refused to meet with Russell Crowe, Billy D Williams performed on "Dancing With The Stars", the couple from "Little Couple, Big World" are separating and from "Divergent" Theo James is here.

L.A had an earth quake this morning, the Malaysian airplane is still missing, Guinness beer pulls out of Saint Patrick's Day Parade, and from "Catch a Contractor" Adam Carolla is here.

A pastor thinks the movie "Frozen" has a gay agenda, Steven Tyler is allegedly dating his younger assistant, passengers on a Carnival Cruise want lifetime retribution, and from "Tyler Perry's Single Moms Club" Tyler Perry is here.

Adam Levine is interviewed.

Chelsea chats with Emily Mortimer about the HBO comedy series "Doll & Em."

Minnie Driver is interviewed.

Guest host Mary McCormack

Guest host Khloe Kardashian

Guest host Gabourey Sidibe

Cameron Diaz chats about writing "The Body Book."

Michelle Dockery of "Downton Abbey" is interviewed. On the panel: Kurt Braunohler, Fortune Feimster and Dustin Ybarra.

Figure skaters Tara Lipinski and Johnny Weir are interviewed. Also: Dov Davidoff, Whitney Cummings and Tone Bell are on the panel.

Sarah Paulson is interviewed. On the panel: John Caparulo, Morgan Murphy and April Richardson.

Julianne Moore appears in support of her film "Non-Stop." On the panel: Jen Kirkman, Beth Stelling and Jo Koy.

Kurt Russell chats about starring in "The Art of the Steal." On the panel: Sarah Colonna, Moshe Kasher and Fortune Feimster.

Scott Speedman talks about his role in the comedy "Barefoot."

Alex Pettyfer is on the guest list.

Guest host Ross Mathews

Demi Lovato is interviewed.

Alison Brie is interviewed. On the panel: Kerri Kenney-Silver; Liza Treyger; Josh Wolf.

Chelsea celebrates Fashion Week. On the panel: Eliza Skinner; Lovi Love; Ryan Stout.

Sharon Osbourne.

Director McG ("3 Days to Kill"). Also: Jeff Wild, Cameron Esposito and Matt Braunger are on the panel.

Emma Kenney ("Shameless") is on the guest list. Panelists: Brody Stevens; Jen Kirkman; Kurt Braunohler.

Mariska Hargitay is interviewed. On the panel: Jo Koy; Janine Brito; Ross Mathews.

Michelle Monaghan ("True Detective") is on the guest list. Panelists: Natasha Leggero; Sarah Tiana; Whitney Cummings.

Vanessa Hudgens is interviewed. On the panel: John Caparulo; Fortune Feimster; Julian McCullough.

Emma Roberts is interviewed. On the panel: Chris Franjola; Sarah Colonna; Dustin Ybarra.

Gabrielle Union is interviewed. On the panel: Ron G; Heather McDonald; Ian Karmel.

Andy Samberg is interviewed. On the panel: Moshe Kasher; Loni Love; and Gary Valentine.

Timothy Olyphant chats about Season 5 of "Justified." On the panel: Michael Yo; Jamie Lee; Ross Mathews.

Gabourey Sidibe talks about her role on "American Horror Story: Coven." On the panel: Kerri Kenney-Silver; Natasha Leggero; Bobby Lee.

David Spade ("The Spoils of Babylon") is on the guest list.

Emmy Rossum talks about Season 3 of "Shameless." Ben Gleib is on the panel, along with April Richardson and Ryan Stout.

Heather Graham is interviewed. On the panel: John Caparulo, Claire Titelman and Ross Mathews.

Kendall and Kylie Jenner promote the Season 9 premiere of "Keeping Up With the Kardashians."

John Leguizamo promotes his movie "Ride Along." On the panel: Leah Remini; Mary McCormack; Whitney Cummings.

Taylor Schilling is interviewed. On the panel: Giulia Rozzi; Josh Wolf; Loni Love.

An interview with Zosia Mamet. Also: Heather McDonald, Julian McCullough and Gary Valentine are on the panel.

Amy Adams is interviewed. On the panel: Moshe Kasher; Fortune Feimster; Dov Davidoff.

Idris Elba is on the guest list, along with panelists Nick Swardson, Sarah Colonna and Michael Rosenbaum.

Kristen Bell talks up Season 3 of "House of Lies."

Adam Scott is interviewed.

Australian author Bradley Trevor Greive is on the guest list.