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In the Romanian province of Transylvania, Lucica Bunghez is being eaten alive, consumed by an 11-stone tumour growing out of her back. Eventually, it will kill her. Lucica suffers from neurofibromatosis (Nf), a genetic disorder that makes the body spontaneously produce benign tumours, and doctors don't dare operate on a tumour that has reached this size. Only one man can help her. Dr McKay McKinnon, at the University of Chicago Hospital, is a world expert at removing large tumours, and Lucica has sent a desperate plea for him to see if he can save her.

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Twenty years ago Terry Wallis fell into a coma. Doctors said he would never wake up, but his devoted mother Angilee never gave up hope. Suddenly, after 19 years, Terry woke up. No one has ever emerged from a coma after so long. Terry is a medical miracle. But this is no Hollywood-style awakening; Terry's mind is stuck in the year of his accident, and he is unable to recognise that he can no longer use his limbs, or that his baby daughter is now grown up. The film also tells the story of British couple Clare and Roy King. Roy was unconscious for just ten minutes following a minor car crash, but the damage to his brain robbed him of the capacity to love his wife and child.