The conviction of a woman found guilty of poisoning a banker is overturned when a laboratory essential to proving the case comes under scrutiny. The subsequent re-trial forces Brenda to ask Provenza's former partner for help tying up loose ends. Unfortunately for the team, more scrutiny occurs when they all discover Provenza's former partner is no longer the man he used to be. The importance of the case may ruin Brenda and Fritz's planned vacation.
Caught in the crossfire of a shootout, two people end up dead and one remains in critical condition. Now Brenda and the team must figure out the the intended crime and the intended victim in order to determine the perpetrator. Brenda and Fritz disagree as they continue to struggle with Charlie, and Provenza drastically alters his lifestyle.
The team digs through several suspects that surface after a man's body is found inside an oversized box. Brenda finds the case the perfect platform to play the role of teacher to Gabriel as he prepares for his detective exam. When Brenda's niece, Charlie, gets out of hand, she and Fritz must consider ending her summer vacation with them.
Brenda must reopen the case of a murdered psychiatrist when the man claiming to have committed the crime gives a statement that doesn't quite match the actual events. Based on evidence of the man's acquaintance with the doctor, Brenda believes there is a cover-up and sets out to unearth the truth. Willie Rae throws a roadblock in her path when she pops in for a visit, which actually appears to be an attempt to dump Brenda's handful of a niece onto the newlyweds during for the duration of summer break.
When an internet matchmaker is murdered, the team finds themselves investigating the matchmaker's early-stage television show. Adding to the craziness is a fake officer, who turns everything upside down. In an effort to school himself on the inner workings of Brenda's group, Pope decides to work as one of the team.
Brenda and the team are called in to investigate the questionable disappearance of a shady financial investor. The team is a mess with Daniels now in another division, Gabriel doing double duty, and Provenza with behavior more curious than usual. In the meantime, Brenda and Fritz deal with a sick Kitty.