The Tick and Arthur are chosen to teach Superhero School and a classroom of unlikely heroes. They must rush into action to take on Uncle Creamy, a corporate mascot turned into a evil ice cream cone who strikes out at the company who made him. Meanwhile Uncle Creamy II attacks, trying to kill Uncle Creamy before he tells the heroes what the company is up to.
Arhtur is annoyed at his failed attempts to lose weight and dismayed at how much of a wimp he is. When he and Tick defeat a villain named Evil, Arthur takes Evil's strength-enhancing belt. When Arthur wears it, he gains confidence and likes seeing himself with a muscular physique. While dating Carmalita, Arthur picks a fight with two guys to show his new strength and confidence. The Tick is called in to end the fight and he tangles with Arthur. In the end, Arthur must get rid of his strength belt to save his and Tick's life. Arthur realizes the addiction the belt gave him and tosses it away so that he can be himself.
The Deerfield Aztecs, a baseball team, crashed in Mexico and formed their own lost tribe of real Aztecs. They track their missing shortstop, Carmalita (Arthur's girlfriend) to America but grab Arthur instead. When the Tick and Carmalita pursue, the Aztecs and their leader Wally unleash ""Speak"", some kind of lowly animal that they intend to wed Arthur to. Tick takes a shine to ""Speak"" (as he names him) and he defeats the Aztecs and rescues Arthur.
Dinosaur Neil, palaeontologist, curator of Dinosaur Grotto and one-time giant city-destroying mutant, is marrying Arthur's sister Dot. Chairface Chippendale, The Breadmaster and El Seed have other plans, though - plans which involve tampering with Neil's medication, man-eating bouquets, exploding wedding cake, and The Indigestible Man. And as if that wasn't enough, Neil's best man is... The Tick! It's up to our blue hero, Arthur and Dot to save Neil, with the aid of a submarine and 1,400 pounds of pungent raw meat...