The Sliders track Rickman to a world where a mad scientist has been experimenting with genetic testing and has created a race of human hybrids.
Wade falls under the spell of a rock band's charismatic lead singer, who is really a vampire and looking to use Wade to get the timer. Meanwhile, the others try to track down Rickman.
The Sliders' chase for Rickman takes them back to the world they helped colonize, the New World. Only they find that the colonists are being hunted by a hungry Tyrannosaurus Rex.
While on vacation, Quinn and Rembrandt get mixed up in an illegal snake deal and find themselves stuck in the middle of no where surrounded by deadly snakes. Meanwhile, Wade and Maggie get involved with a shady man in their search for the others.
The Sliders track Rickman to a superstitious town. Their search is further complicated when Quinn and Maggie are captured by natives living in a mysterious fog. There, Quinn runs into someone from his past--himself.
Wade and Rembrandt recall their slide to a world plagued by earthquakes and populated by primitive people. Wade falls into a deep chasm and Quinn goes to rescue her, while Rembrandt learns of Arturo's illness.
A creature embeds a parasite in Maggie just before the slide, which takes the Sliders to a world where young adults are used in a mandatory organ-donor program. The others will have to find Maggie before she finds the perfect mate and lays her eggs.
The Sliders arrive on a world where a strange bacteria transformed the inhabitants into flesh-eating zombies. When Quinn is bitten, he begins to turn into one of them.
Quinn and Maggie return to her world with Earth Prime's coordinates stored in Jensen's timer. As Wade makes the final list for those who can slide to safety, Arturo races to modify the new timer to slide more people. Unfortunately for them, an unexpected danger lurks the base and one Slider will not make it to the next world.
Things don't look good for the Sliders when they slide to a world that's about to be eradicated by a rogue pulsar. Soon they discover that this world has been developing sliding technology and pool their resources with the U.S. government in a race to escape to a parallel Earth.
The Sliders arrive in a small community, where the citizens are all young and fearful of outsiders. They don't expect much trouble, until they uncover a deadly secret.
On a world ruled by Egyptian culture, Quinn is used in a life-after-death experiment and thought dead. The others miss the slide when trying to save a woman from a sacrifice and become trapped in a pyramid with a big scarab.
On an over-worked world with an uptight population, Arturo is thought to be a fracture and is sent to a fantasy camp for a form of relaxation. When the others find him, they see he has been brainwashed into thinking he is a great detective on the trail of a Jack the Ripper-like murderer.
On a world where people are enticed by consumerism and giant malls in the sky, the Sliders get jobs as mall employees to find the mother of an abandoned child. Arturo is a reluctant Santa, Rembrandt and Wade his elves while Quinn gets an administrative job. Meanwhile, Wade faces some strong emotions when she meets her sister and father.
The Sliders land on a world where the human race was wiped out by robots. Quinn and Rembrandt are captured by the robot's demented creator and are going to be used in a mind-transfer experiment.
On a world where the legal system is in the form of televised game shows, Quinn is arrested, tried and sentenced to death for the crimes of his double.
On a world where the American government is a monarchy, Rembrandt is mistaken for his double and discovers that he is about to be a father of royalty. The only problem is, on this world, it's the men who give birth to children.
After barely escaping a world engulfed in flames, the Sliders now find themselves in a Los Angeles dependent on the sale and production of oil. Unfortunately, they learn they've brought along a piece of the fire from the last world and that it has a mind of it's own.
On a world of magic and dragons, Quinn is mistaken for a wizard and kidnapped by an evil warlock bent on immortality. Meanwhile, Wade tries to help Rembrandt's love troubles with a love potion, but it backfires and makes Rembrandt fall in love with her.
The Sliders land on a world with little water and come to the aid of a mysterious young woman whose gift to find water is being exploited by a group of thugs.
On a world where a group of social misfits have learned to torture people by entering their dreams, Wade becomes a target of the group's leader.
The Sliders arrive on a world just like their own, only time is moving at a rate of twelve years slower than normal. There, Quinn encounters his young double and tries to change an upcoming event in his life, despite the other Sliders' warnings.
The Sliders arrive on a world where electric tornadoes have almost completely wiped out the population. They find a secluded village somehow protected from the tornadoes and a dictator that may prevent the team from ever sliding again.
On a world quickly running out of natural resources, Rembrandt meets his number one fan but finds her to be a little too friendly. Meanwhile, Quinn and the others meet Logan, a scientist at Prototronics that's trying to develop sliding. However, they learn her plans for sliding are far from noble.
The Sliders become involuntarily apart of a human war game where the only winners are the ones that stay alive.
