When Susan and Mary turns Johnny into a fish as part of one of their experiments, Hugh flushes him down the toilet by mistake where he ends up in the sewer, and he has to swim for his life when he runs into an alligator.
Johnny gets a wart, and when his sisters try to get rid of it, it gives the wart intelligence and seems to make Johnny's life better, but he tries to take over his body as he gets more powerful.
Johnny is dragged into Susan and Mary's plan to get Gil to be in a sleep-over, but Bling-Bling Boy and Dark Vegan's daughter Jillian become involved as well, with the usual chaos ensuing.
It's Lila's birthday and the family spends the morning to make her birthday a success. Johnny struggles to make her breakfast, Hugh tries to figure out a good but inexpensive gift for her, and the twins keep trap Lila in her bedroom until Hugh and Johnny are ready.
Johnny uses one of his sisters' inventions to bring two cartoon characters to the real world in order to scare Sissy out of the house, but the characters mistake Porkbelly for a zombie world and try to destroy it.
Susan and Mary both want Gil to go on a date with them, so they put up a wrestling match using rough guts (Susan uses Johnny's while Mary uses a lion's), but it leads to destructive results.
Johnny's parents keep setting Johnny up with new friends. When those don't work out, Johnny reveals Dukey's intelligence. Later, Dukey spends more time helping Johnny's parents instead of playing with Johnny.
Johnny and Dukey challenge his sisters, their friends, and their enemies to a survival challenge in which the winning team gets hundreds of dollars in gift certificates.
Johnny travels to 1845 when school was easier, but he gets stuck there because the power supplier to the Turbo Time Tea house hasn't been invented yet. The sisters and Johnny try to find outdated technology to power the tea house.
Johnny wants to get a trophy to put in his trophy case. Susan and Mary get obsessed with winning, so the three of them enter The Pork Belly River Jumpoff to win 1 million dollars and a trophy.
Johnny goes back in time in order to get a sloth bone for the twins, but when he returns he becomes a caveman, interfering with his grounding from selling Hugh's personal items.
After Johnny lands his bike into a garbage truck, he becomes a Lady Bird Scout and tries to sell 1,000 boxes of cookies to get a new one. Little does he know, Sissy wants the bike as well, but for a better reason.
Johnny tricks his sisters into letting him have teleporting powers. Susan and Mary mess with the powers to get revenge. Later the twins accidentally get them caught in a middle of an art robbery.
Susan and Mary purposely turn themselves into babies while the parents are out, and Johnny has to keep them safe from the irresponsible babysitter Gil; this interferes with a party he and Dukey had been planning.