A warlock repeatedly attempts to kill the Charmed Ones, with a help from demon Tempus turning back time after each failure so that he can try again. However, because of the endless time loop and her power of premonition, Phoebe experiences a number of strong cases of déjà vu and is able to figure out that there are evil forces after them.
The sisters are about to go on a relaxing weekend getaway to Cabo, when a mortally wounded Leo shows up and asks for their help to save a young woman who's being chased by a darklighter. Desperate to save Leo, Piper casts a spell that swaps their powers, however in doing so, she accidentally swaps the powers of Prue and Phoebe as well. Meanwhile, pressed by an Internal Affairs investigation Andy decides to leave his job in order to protect Prue's secret from being exposed.
After Piper leaves on a business trip, it doesn't take long for some friction to appear between Prue and Phoebe. However, they set their differences aside when they run into a ghost of a serial killer who's looking for a revenge against people who sentenced him with a death penalty. Meanwhile, the many unsolved crime cases are finally starting to catch up with Andy when people from Internal Affairs take an interest in them.
When Prue witnesses and tries to stop a kidnapping of a young boy in the park, a reporter sees her using her powers. He tries to blackmail her to get a sensational story for his newspaper. Phoebe and Piper attempt to learn more about the demons who stole the child and come across a similar kidnapping that happened 20 years ago. Meanwhile, Andy gets involved in the kidnapping case and finally confirms his suspicions about Prue's powers.
The sisters' mother warns them about a demon from the underworld who comes around every 1300 years on Friday the 13th to literally scare witches to death and feed on their fear. Meanwhile, Phoebe has misgivings about her expected duties at her new job and Piper is frustrated by her superstition about relationships started on Friday the 13th.
A warlock from the past is released from his curse and tries to steal the sisters' powers with the help of Rex and Hannah, but the sisters resurrect their ancestor to combat him. Meanwhile, Piper works up her courage to ask Leo out and Andy gets frustrated by Prue's continued involvement with bizarre police investigations.