When a person who was killed right in front of Phoebe comes back from the dead to blame her, she becomes guilt-ridden and vulnerable, creating an opportunity for Zankou to steal the Book of Shadows. Meanwhile, Paige has a new charge who knows nothing about magic, and Piper and Leo attempt to plan Chris's first birthday party.
The sisters scramble to recover Pandora's Box when it falls into the hands of a shapeshifting demon who intends to open it and fill the world with all of its sorrows. Meanwhile, Paige's Whitelighter side rises to the surface, when she begins hearing calls from the Elders, and Leo and Piper clash over parenting issues - namely raising magical children.
In an attempt to lure the sisters out of the manor, Zankou sends his underlings to attack Leo, in order for him to search the house for the Nexus and release the Shadow, the ultimate power. Meanwhile, in order to protect his parents Wyatt magically shrinks them and traps them inside a dollhouse, and Phoebe is left in charge of the newspaper.
Piper is attacked by demons and winds up in a coma, and as she hovers between life and death, her spirit meets a familiar face who wants to help restore Phoebe's faith in love. Phoebe, Drake & Paige rush to save Piper by attempting to locate Leo, who's memory has been wiped clean by the Elders in attempt to allow him to choose his own destiny: be an Elder forever or choose Piper, and become mortal.
When Daryll's friend is possessed by the spirit of an innocent killed in a fire in 1899, Phoebe and Drake transport themselves back in time to the caberet where it happened. However things go from bad to worse, when they find they cannot travel back to their own time. Meanwhile, Piper convinces Leo they need to take a family vacation.
When Piper switches powers with Phoebe, to allow her to see the vision of the utopian world, Zankou interferes, and causes their powers to be transferred to innocent bystanders, who run amok. Meanwhile, Brody's murderious desires prompt Paige to take him on a journey back to his childhood to learn the truth about his parents' death.
In an attempt to stop a demon on a murderous rampage upon his human relatives, Paige casts a spell that inadvertently blocks all death, and it's up to the Charmed Ones to make things right, when the Angel of Death wants the mess cleaned up. Meanwhile, Agent Brody reveals that he has been following the Halliwells longer than they thought, and Phoebe must deal with her feelings toward Leslie.
When Paige encounters Captain Black Jack Cutting, an 18th century pirate in search of the Fountain of Youth, the curse on his life becomes her problem. Meanwhile, Leslie manipulates a contest in order to spend time with Phoebe, Leo fights with the creature that caused him to kill an Elder, and a mysterious federal agent comes to town to investigate the Halliwells.
When Paige and Phoebe summon Grams for Chris's wiccaning, Grams puts a spell on the children to try to end their sibling rivalry, but instead it reverts the sisters back to bickering teenagers. Meanwhile Phoebe, still acting like a teenager, attends an award ceremony with Les, and Leo consults a demonic seer to find out who is behind the attack on Wyatt.
The Charmed Ones have their hands full, when thanks to a bored Magic School student, they must keep Lord Dyson from killing the infamous Lady Godiva before she can travel back in time and complete her famous ride. Meanwhile, Phoebe has reservations about Les being able to properly write an advice column for women.