A girl adopted from China undergoes heart surgery for an unknown cardiac problem. A doctor gets stitches in his forehead from a colleague. Dr. Andy Cameron has trouble balancing his life as a transplant surgeon and as a father.

A surgical resident makes a mistake that causes a patient to have surgery. A pediatric resident cares for premature infants. A surgeon takes on a 3 way kidney transplant. A transport nurse tries to save a child during a transfer to Hopkins.

Having left a career as a successful dentist for a career in surgery he was told he could not have, a tough–talking plastic surgeon demonstrates skills unmatched anywhere as he makes the ugly beautiful and gives those without hope a future. Also three eager medical students jump at the chance to participate in patient care, but find that patients are less than thrilled to be guinea pigs.

Peyton, an apparently healthy toddler, is diagnosed with a severe heart condition. His parents must decide whether to wait for a heart transplant to to let him deteriorate. Tom Reifsnyder discusses his marital travails and his comedic surgeries. Ann Czarnik returns home to West Virginia.

Ann Czarnik is a doctor from West Virginia who is surprised by the carnage of the ER. Earl Ingman is in need of more than just a heart transplant. Brian Bethea tries to reconcile with his wife, Amber.

A woman badly in need of a lung transplant waits to find out if an available organ is a good match, an ER doctor weighs the pros and cons of marriage, and a heart surgeon is kicked out by his wife.

A doctor who entered the U.S. illegally in the 1980s has become a prominent brain surgeon. Also, continual high-pressure situations take a toll on the life and marriage of a heart surgeon.