Arcadio enforces liberal rule in Macondo, while Aureliano attempts to free a colonel from the conservatives. The looming threat of war finally arrives.
Arcadio becomes the school's principal, and Pilar has significant news for Aureliano. Remedios fills the Buendía home with joy — until tragedy strikes.
An odd girl brings a delirious sickness to Macondo. José Arcadio becomes fascinated by Melquiades' camera. Rebeca and Amaranta vie for Pietro's attention.
Aureliano has visions of a war, while José Arcadio Jr. meets a woman. José Arcadio's alchemy obsession pushes Ursula to find a way to support the family.
Fearing a ghost and a curse, Úrsula and José Arcadio leave their town to establish a new home along a few others, braving a journey through tough terrain.