As a young child, Allison Tate had discovered the bodies of her parents, apparently killed by an intruder. Shortly after her twenty-first birthday, she found the body of Marsha Gold, killed in a similar matter. When this thrust her back into the Linder Sanitarium in which she'd spent most of her life since her parents murdered, Bob Ranier (her father's former business partner, like an uncle to her) hires Matlock to prove that Allison is innocent of her murder. Matlock has an unlikely ally in Warren Kreitzer, an insurance attorney who is supposed to be on vacation, but will do whatever he can to protect Allison.
Matlock agrees to defend Vanessa Douglas when she's accused of murdering Stephen Cassidy, and author who destroyed a political families ambitions with a tell-all book. When Matlock realises his client is indeed guilty of the murder she is charged of committing, he sets up a plan to implicate her best friend, Sarah, with the crime, knowing that Vanessa will not let her friend take the blame for something she did.
Michelle agrees to defend college chum Andrea Morrow after she is accused of murdering her abusive lover, Clay Graham. Matlock soon becomes convinced that the murderer was Clay's blind 'friend', Arthur Hampton, but will have a devil of a time proving how a blind man managed to carry off a near-perfect murder.