A 29-year-old man gets tooth pain and almost dies of necrotizing fasciitis caused by the bacteria Streptococcus intermedius and Peptostreptococcus; a female financial adviser gets fatigue, joint pain, mental confusion, hair loss, and muscle weakness for over three years from Lyme disease; a 7-year-old boy gets a loss of appetite, abdominal pains, a fever, diarrhea, constant vomiting, and weight loss from Cryptosporidium.
A Canadian 13-month-old toddler gets breathing difficulties and mild vomiting from accidentally swallowing a button battery (for what the doctors originally thought was a coin); a college freshwoman gets migraines, nausea, on-and-off blindness, hallucination-like partial seizures, repulsive taste and two lesions in her brain from infection with Taenia solium; in 2008, a 6-year-old girl gets a headache, a rash, high fevers, and dies from Rocky Mountain spotted fever.
A teenager gets coughing, shoulder pains, dizziness, and nausea from Cryptococcus gattii fungi invading her lungs; a saleswoman gets extreme pain in her breast from a brown recluse spider (Loxosceles reclusa) bite; a religious youth organizer gets swelling of multiple parts of the body over the course of three years from the Loa loa worm.
The second episode of the series to be Christmas-themed – a saleswoman gets a stabbing headaches and a constant burning sensation in her right eye from a Dirofilaria immitis worm that is in her eye; a store manager gets stomach pains, fatigue, nausea, vomiting and even a constantly moving stomach from a surgical sponge being left and forming a hole in his colon; a grandmother working in the forest service gets abdomen pains, fatigue, and pneumonia from Strongyloides stercoralis worms invading her intestines.
A war veteran suffers fatigue, high fevers, night sweats, strange rashes, bloody urine and jaundice from babesiosis; a 15-month-old baby girl suffers fever, dry mouth, vomiting and bloody diarrhea from E. coli O157:H7, whom she got from drinking raw milk; a biologist suffers extreme fatigue, back pains, anxiety, and vertigo from Aspergillus-contaminated breast implants
A Canadian science-lover and traveler suffers a painful lesion caused by botfly larvae; a video game programmer gets suffers from constant vomiting and coughing. When doctors find a large mass in his chest, it is discovered that he has histoplasmosis, which was contracted from inhaling bat droppings in a cave; a 15-year-old girl gets an extremely sore throat, a headache, nausea, and body pains from Lemierre's syndrome.
A contractor gets hit in the head with a tool, and later starts getting a pounding headache, dizziness, spotty vision, and nausea from having a nail punctured into his brain; a football player in college gets extreme headaches, a stuffy nose, and blurred vision from Aspergillus fungi entering his brain; in 2012, an 8-year-old boy suffers constant vomiting, fatigue, seizures, and eventually dies from amoebic meningitis after being infected with Naegleria fowleri.
A 23-year-old athlete/construction worker suffers multiple grand mal seizures and high fevers from eastern equine encephalitis; a hard-edged tough guy suffers severe stomach pains and loss of appetite from accidentally swallowing a grill bristle; a 17-year-old cheerleader who recently got her driver's license suffers a swollen, itchy eye and excruciating eye pains from Acanthamoeba keratitis she got from contact lenses.
A teenage girl begins having strange mood swings from anti-NMDA receptor encephalitis; an elderly mother gets chills, hand numbness, wrist pain, and oozing blisters from Vibrio vulnificus she got from being pricked by a crab while making a stew; an athletic military veteran from the Afghan war competing in reality shows returns home from Fiji feeling hotness, a pinching sensation in her arms and toes, and hallucinations from rat lungworm she got from eating a slug in a reality show in the jungle