Once again Ms. Garrison gets dumped, but this time she decides to take it out on her fourth grade class. When the boys have finally had enough of their teacher's erratic mood swings and excessive homework assignments, they find out that there are people-for-hire that can help out in any situation. Meanwhile, Ms. Garrison is finding life without men has its upsides.
The citizens of South Park are gearing up for the arrival of Hillary Clinton for a big campaign rally. Meanwhile, Cartman suspects that a new Muslim student is involved in a possible terrorist attack. Every minute counts for Cartman as he uses his own interrogation methods on his suspect. But could the plan to target Clinton be just the tip of the iceberg?
When a breakout of headlice hits South Park Elementary, Mrs. Garrison refuses to say which child brought the plague to the school. So, Cartman takes it upon himself to find out who it is so the kids can make fun of them. Meanwhile, a louse Travis, is desperate to save his fellow lice from imminent destruction from a conscious world.
Butters' dad sends him off to special camp to "Pray the Gay Away" when he believes that his son is bi-curious after catching him in a compromising position with Cartman. Meanwhile, Cartman does his best to retrieve a photo of him in that compromising position before too many people find out about it.