Brain takes control of a satellite to air his infomercial around the world, but the satellite belongs to the military and they want to capture whoever hacked into their systems.
Mr. Itch offers Brain control of the world in exchange for his soul, but Brain refuses. In a shocking twist, Pinky sells his soul to make it happen and Brain soon decides to get his friend back.
In their latest plan, Pinky and Brain try to take over the steel mills in Pittsburgh, Pennsylvania by pretending to be a part of an endangered species called the Mousealopes.