Detectives in Sydney launch an epic search for a tourist with life-threatening medical conditions and the beloved brother of a best selling author goes missing in Victoria.

Police must defy all odds to find a missing four-year-old girl and a young Geelong teenager runs away from home.

Two men go missing in remote bush after a boys' weekend goes terribly wrong, and detectives discover disturbing new details in a 20-year-old cold-case of a missing teenager.

A father disappears in croc infested waters and a young girl walks out of her family home and never returns.

When police hit a dead end, a young woman stops at nothing to find her missing brother and new breakthrough forensic techniques may hold the secret to a 30-year-old mystery.

A man goes missing in mysterious circumstances and a patient flees hospital after a suspected heart attack but no one knows why.

Police launch two large-scale searches to find a father of two who goes missing off the WA coast, and a navy veteran lost in hazardous bushland.

Detectives in Sydney investigate the case of a young woman who has vanished in mysterious circumstances, while in Melbourne, police race to find a man missing during a storm.