Spacely convinces all his employees to take an aptitude test and makes sure George scores the lowest. But when Judy, Elroy and Astro alter his father's score to be higher than everyone else's, George is given charge of Spacely's plant for the day when his boss is forced to take an impromptu vacation. Upon discovering that George is in charge of Spacely's plant, Cogswell makes plans to destroy Spacely Space Sprockets once and for all and attempts to ensure that George takes the fall.
It seems that Orwell Spacely, Mr. Spacely's nephew, is the company's inventor. George becomes the company's Guinea Pig. Just when the patrolling police think no one breaks the 500 mph speed limit, they see a car driven by a man without a face. The new invention doesn't clean people like it is supposed to, it makes them invisible!
Elroy invents an evolution machine. By mistake his evolutes Astro by 10,000 years, increasing his I.Q. by 4000 points. George bets everything he owns by playing chess with a little help of Astro. At that moment Astro is caught by the dogcatcher. When that doesn't work he enters a brainy game show where the contestants can win millions.