After a prolonged absence Master Shake returns to his humble abode with a big new voice and an unconscious rabbit. When it is revealed that Shake and the rabbit have undergone a Freaky Friday style body swap, Frylock, Meatwad, and Carl attempt to set things right by way of public urination at the local Powerpuff Mall.
At long last Meatwad discovers the wonders of friendship. Unfortunately he falls in with the wrong crowd, a cocaine addicted amateur porn crew and their star actress Jubilee. Frylock races against time to prevent Meatwad from losing his virginity on film while Carl and Master Shake vie to take Meatwad's place in a kinky ménage à trois scene.