Evil scientist Ami and her assistant Yumi create the perfect manager, "KAZ". When Harmony, their Number 1 villager, gets into their castle, the monster escapes and gets into Harmony's house. When he leaves again, he pushes over a table with candles on it, causing the house to burn down. Harmony gets angry and organizes a mob of villagers to storm the castle. Meanwhile Ami and Yumi are making another monster. They hear the door-bell and, when they open the door, Harmony and two other villagers run into the castle and start to destroy it. Suddenly Kaz comes back and Yumi finds out that he had only been behaving strangely because he could not see. She gives him glasses and then he convinces the villagers that they are not mad scientists, but musicians. To thank Kaz, they make a wife for him. This is the series finale.
Julie (Lara Jill Miller) comes for a visit. She does nice things to Yumi, but mean things to Ami(Such as calling her Arthur and pretending she doesn't exist). When they go to their concert, Julie is not treated as a star. When the concert is over, she goes to a dark alley and plots revenge.
Kaz gets sent into a manga where he is captured by Mr. Maestro. Ami and Yumi try to rescue their manager with the aid of two heroes, a pencil, and an eraser.
Ami's cell phone overuse causes Kaz to take her cell phone away, leaving Ami to find alternate methods to communicate with other people.
The girls are denied access to the Rock Legends museum since they've never trashed a hotel room. Ami and Yumi try their best, but the plan becomes thwarted by an efficient maid.
Ami and Yumi travel back in time to become disco stars.
An alligator named Waldo appears and startles Ami and Yumi. The girls then try to get rid of him.
Kaz accidentally knocks out a horse named Butterscotch, and Ami and Yumi dress up as the horse to help Kaz out at a rodeo.
When Yumi is struck by lightning, she is sent to an alternate universe where everyone is evil. Meanwhile, Yumi's evil counterpart is put in Yumi's place and wreaks havoc.
Ami, Yumi, and Kaz get lost in space as they head to their next gig.
Kaz tries to find a way to carry Ami and Yumi's instruments to their next gig without the need of a tour bus.
When Ami and Yumi shrink in the drier to mouse size, they need to find a way to get back to normal size while being chased by their own cats.
The show is spoiled because the animators fall asleep. Yumi has Kaz's voice, Ami has Yumi's voice and Kaz has animal voices.
Ami joins Kaz's football team, not knowing that this is a dangerous sport. Kaz tells the security guard not to let Yumi in, because he does not want her to stop Amy playing. Yumi dresses like a cheerleader and gets in. Seeing that Ami doesn't have a chance against the other players, Yumi helps her without Ami realising it.
When Yumi accidentally injures the tooth fairy, she and Ami become tooth fairies for one night. But soon they meet a little boy who would do anything to keep his tooth.
With the help of the girls, Kaz trains to become a sumo wrestler and has his first match.
The girls play a game of Truth or Dare.
The girls go to a prom in the jungle, but are in danger of missing it.
Ami, Yumi and Kaz have trouble with a mime named Si. And need a way to get rid of him.
Ami, Yumi and Kaz are too old to be rocking and need to find other enjoyable things to do.
A gang of bikers attacks a city. The girls must stop them before they take it over.
The Talent Suckers use zombies to increase their popularity, but it proves ineffective.
The girls need to find a way to hide their rock-star lives from Ami's grandmother incase she suffers a heart attack.
Ami and Yumi win 1 million Yen. They have to think of a way to spend it all in only 6 minutes.
The girls and Kaz try out for a sitcom, hoping for good reviews but recieve continuous bad reviews.
When their instruments break, Ami and Yumi go on a quest for golden fleas. They need to find them before the concert is canceled.
When their instruments break, Ami and Yumi go on a quest for golden fleas. They need to find them before the concert is canceled.
Ami must fight the Black Knight to see who will defend Kazalot.
While focusing on Puffy AmiYumi, Harmony is disturbed by a member of the Junior Tapeworms and she soon becomes a member and is always getting a badge for every achievement she does.
After coming to life, Ami and Yumi's favorite manga characters battle each other. The fight gets out of hand and it is up to Ami and Yumi to stop them.
Yumi is mistaken for a secret agent and must handle the real Agent Y's job.
Jeng Keng and Tekirai clone themselves to get rid of Domo after failing the first time.
In prehistoric times, Primitive Ami and Primitive Yumi create their own music, and Primitive Kaz tries to get the two to join together and form a band.
Ami asks Wall to help out with the band, but he is not good at it.
Ami and Yumi have to stop other people seeing an embarrassing photo of Ami in the newspaper.
Yumi is chosen to be a movie star, but Ami has to be her stunt double.
The tour bus is acting erratically and Ami and Yumi go inside to find out what is wrong. They find out that the man who sold them the bus had moved into its carburetor. The girls get him out and the bus is fine.
Yumi needs a new guitar and must accomplish certain tasks to get one. So she meets Master Mei Pie, who sends her to get some items. She collects all the items, but realizes that she was not focusing on her playing.
In their childhood years, Ami and Yumi arrive at Camp Youwannasushi and are met by Atchan, who tells them about Rumaki the bunk monster. Yumi is grabbed by Rumaki and Ami and Atchan go under the bed to save her. They manage to save Yumi, but she does not believe them because she was in the sack for the whole episode.
