Dr. Mark Sloan (Dick Van Dyke) reprises his role as the crime solving doctor in this tv movie based on the television series. When a large group of Mexican workers are infected with a deadly virus, Dr. Sloan and his friends must figure out the cause and cure for it before it's too late.

In Los Rios enroute to Los Angeles, Carol makes an urgent call to her father, Dr. Mark Sloan, pleading for help. Arriving in the small, seemingly pleasant mountain town, Mark investigates but the whole community denies knowing anything about his daughter and her husband.

Dr Sloan suspects that his flame of long ago, famous heart surgeon Dr Rachel Walters, has murdered US Senator Cabot on the occasion of a guest operation at the community hospital.

Dr Mark Sloan cannot believe that his former student Dr Drummond, an ambitious cosmetic surgeon, has committed suicide. Assisted by his team of hobby detectives, pathologist Amanda Bentley and junior doctor Jack Parker, Sloan tries to investigate the case.

Police detective Steve Sloan believes that top manager Nick Osborn has killed his boss, trust-owner Russell Cord. His father, senior hospital doctor Mark Sloan, is convinced that his long-time patient Osborn is innocent and soon discovers three other top employees of the Cord Group who also had reasons for killing their boss.

Dr. Sloan is charged with murdering hospital director Havilland, who was investigating him and two other doctors. Jake and the Fatman: Season 4 Episode 19