Sam wins a spot on the hot new game show, 'The Main Brain.' The following day, when Sam begins to lose her memory. Investigation by Alex and Clover reveals that game show host Larry Large is stealing his contestants brainpower and putting it into the mind of his waitress-girlfriend, Margie so that they can dominate the airwaves and eventually the world!
For absolutely no reason at all, all these dating booths appear out of nowhere and all the girls in Beverly Hills, Sam, Alex and Mandy included, are addicted to them and get very hunky boyfriends in the process. But Clover suspects something is wrong and decides to get to the bottom of it, even without Jerry's help.
While they were looking forward to a fun weekend away from WOOHP the school ski trip becomes a disaster when Sam, Clover and Alex find themselves sharing a room with Mandy. If that's not bad enough one of their old enemies has escaped and is looking for revenge so they have to avoid getting killed and capture Dr Gelee without tipping off any of their classmates that anything strange is happening.
Clover has a hot date with a football player, and manages to drag Sam and Alex along to go with tweedle-dee and tweedle-dumber. When the girls are called away on a mission to explore a break-in to the office of secret information, the girls are lured into a trap when the guy escapes through the elevator shaft. Leaving the girls dangling at the 75th floor. With no gadgets and almost no way out, the girls prepare themselves for remembering the good old days at WOOHP.
When Alex screws up on several WOOHP missions, she begins to seriously doubt her spying abilities. Then, when Jerry introduces the girls to Britney - a pretty, smart, sweet, spy-in-training who's been assigned to help them on their next mission - Alex only feels worse. When she screws up again and lets a villain escape, she decides to quit WOOHP altogether.
Seemingly ordinary women across America keep going berserk and attacking men and unaffected women. All of the berserkers turn out to be descendents of an ancient guild of warrior women who intended to wipe out all men and inferior women. They failed but someone's reviving the idea using their descendents and Sam's one of them!
With Jerry off fishing with the President in hopes of wangling a White House appointment the girls get stuck babysitting the president's 11 year old daughter Madison. Problem is that years of putting up with being surrounded by the media and the secret service have turned her into a real brat whenever her father's not around. All of which means the girls are keeping their distance making it easy for a giant robot spider to kidnap her and a mystery man demand a mad scientist be released or else Madison's never coming home!
Looking for Mother's Day gifts for their mothers, Clover, Sam and Alex find a flyer about a special offer at a spa. But after they get there they notice that their moms are not behaving normally. They find out that their arch nemesis Tim Scam has escaped from prison and has taken over their mothers. Jerry on the other hand is spending Mother's Day at his mom's house.
Zanzibar is winning every event in the Winter Olympics despite the fact they aren't even training. The spies go undercover at the games to find out if the team's coach has developed a new and undetectable method of cheating but find themselves in hot water. Or rather cold water as Sam and Alex face drowning in an icy lake while Clover undergoes another bizarre physical transformation.
Redheads start vanishing worldwide after visiting the new Cutting Edge Hair Salons. Sam figures she's the ideal choice to investigate but it seems whoever's behind it has made their quota. However they're still short of blondes and before too long it's up to Sam and Alex to save Clover and the other girls before The Harvest begins.