As Pete waits for glaucoma surgery, he and MacGyver reminisce about their past adventures and try to figure out who has been sending some vaguely threatening messages to Pete.
A land dispute over the building an electricity station pits a fanatical Native American, convinced he has been given a mission by his spiritual ancestors, against the power company and MacGyver, who's just as sure that the Indian spirits are opposed to the man's violent plans.
Murdoc wants to come out of retirement, but his former employers at Homicide International request that he take out MacGyver as a demonstration of his sincere desire to rejoin them.
Mac finds himself being cared for by two determined ladies running a bed and breakfast in an isolated spot chosen as a drop spot by two murderous mobsters with an untrustworthy partner.
An old sweetheart of Pete Thornton's appeals to him for help when she tries to reveal the atrocities being committed in her Latin American homeland.
Mac feels a personal involvement in the death of a priest who worked among the homeless and takes to the streets himself to find the killer.
Mac tries to help an acquaintance just out of prison stay on the straight and narrow despite the efforts of his old biker gang to blackmail him into rejoining them.
Mac helps out on an archelogical dig for Alexander the Great's tomb. But the expedition seems to be followed by bad luck. Several incidents nearly causes a shut-down. Then Mac finds clues leading to Alex's tomb. Unfortunally, the accidents are not coincidental, and they meet a very vengeful man who traps them inside the grave...
Mac seeks to stop a shortsighted developer whose latest project will create an environmental ruin and could result in his premature death at the hands of his greedy children.
Mac is reunited with a high school sweetheart whose husband is a wealthy man sponsoring an international sports competition.
Mac defends a former player's daughter being blackmailed by a baseball memorabilia-counterfeiting ring trading on her father's name.
Mac uncovers an out-of-this-world scam when he investigates some mysterious indentations in a farmer's field.
MacGyver goes undercover to investigate the death of a farm-worker organizer during an investigation of illegal pesticide use.
Macgyver's reluctance to commit to a permanent relationship causes him to dream an Old West scenario where he defends three of his lady friends from some ornery outlaws as he drives their wagon cross country.
When Mac tries to claim the station wagon left to him by his late Grandpa Harry, it starts a strange chase that leads him to an ex-con with a dream of running a restaurant, a soup kitchen in need of money, and a gang of crooks out for themselves.
Dr. Zito returns to menace MacGyver and Murphy when he escapes after his latest sanity hearing, leaving a series of nasty clues designed to give Mac a crash course in evil.
MacGyver helps reunite an East German girl with her grandfather in America, unaware that she's been recruited by two bitter former Stasi agents who believe the old man possesses a store of hidden gold.
MacGyver tries to help his teenage friend Lisa admit she has a drinking problem, but it takes a brush with the law when she's implicated in a string of home break-ins to really wake her up.
MacGyver searches for a gun used in an assassination twenty years ago and in a present day cop killing to clear a friend.
MacGyver and Thornton are left to the mercies of a Romanian agent still loyal to his deposed leader Ceausescu after a mission to obtain his secret files is sabotaged.
MacGyver's pacifist policies are put to the test by a militant youth leader he hooks up with to find out who has been organizing a gang of youthful vigilantes using extreme measures to clean the neighborhood crack problem.
