Luther turns sleuth to find out who is responsible for the mercy-killings; Dr. Turner takes a chance doing experimental fetal heart surgery; Axelrod gets back at Novino and Griffin; Morrison buys a gun to protect his family; Yvonne Galecki Craig comes to claim her daughter, and Ehrlich and Papandrao have second thoughts about marriage when the new owners fire everyone in the hospital.
Fiscus waits for a woman artificially inseminated with his sperm to give birth; three young men explore life and the hospital to relieve the boredom of their stay; Dr. Westphall relives part of his past when a childhood friend reminds him of an old pact; and Drs. Craig and Auschlander continue to search for hospital financing.
Rosenthal tries to help her obese daughter cope with her problems; Axelrod's father brings a dog to the hospital for chemotherapy; Dr. Turner reluctantly reveals the ultrasound results to a couple looking for the perfect baby; and Dr. Westphall continues to try and find a way to keep the hospital open.
Axelrod allows Novino and Griffin to override his judgement; Dr. Kiem worries about her long distance marriage as she tries to help an inseparable couple make a final farewell; Luther tries to help Polly make it through a day without her medication; and Ehrlich goes to great lengths to confirm the Oseranskys' story.
Dr. Turner finds her confidence shaken when she learns her new patient, about to undergo a risky transfusion procedure, has a malpractice suit pending at another hospital; Dr. Peltrovich arrives but has trouble getting licensed to practice medicine; and Morrison explodes during a mock war with paint guns.
Dr. Fiscus is shot. Afterwards, he experiences the afterlife and meets some old friends. Such people include old patients who died in the hospital, a few in limbo and a couple in heaven. However, he is condemed to hades and finds Dr. White swiming in circles for all eternity in a boat with only one oar. Meamwhile, the docs at St. Eligus try their hardest to keep Fiscus alive.
Mandatory drug testing causes a deep division of opinion; Morrison is haunted by his day at the prison; Axelrod is assigned to guide a 14-year-old medical student around; Griffin gets a warning from Dr. Westphall about hurting Lizzie; and Dr. Craig tries to perform magic tricks for some young patients and his housekeeper.
Dr. Craig behaves boorishly to his replacement, Dr. Paulette Kiem; Birch finds a radioactive patient; Papandrao claims Ehrlich as an escort to a family birthday party; a friend of Fiscus' is admitted with a major stroke; and a hospital neighbor becomes very upset when she observes Dr. Craig's imminent departure.