Jamie and Joe search for an undocumented teenage girl who has been sex-trafficked; a woman in witness protection is murdered; Frank calls out the district attorney's office for instituting a new rule that classifies armed robbery as a misdemeanor.
Erin is stalked by a man who was recently released from prison; Jamie works to save his badge when he is caught driving under the influence after he is unknowingly given drugs at a party; Frank navigates multiple family issues.
A local celebrity asks Frank to make an exception to the NYPD age limit; an encounter with an old rival leads Erin to look into an alleged wrongful conviction; Jamie is torn over whether to report a sergeant; Danny and Baez look for an abducted kid.
Frank is blindsided when Mayor Chase bypasses him with a request for Jamie to head his security detail; Danny and Baez investigate the murder of a wealthy college student; Anthony fears money woes are leading his sibling down the wrong path.
Frank, Baker, Garrett and Gormley experience feelings of guilt when Detective Angela Reddick (Ilfenish Hadera), an officer they briefly worked with at 1PP, is shot after Frank reassigned her for not meshing with their team. Also, Eddie, Danny and Baez investigate a man’s murder after Eddie and her partner respond to an altercation between the victim and a neighbor, and Anthony finds himself at a crossroads when he’s offered a promotion that strains his relationship with Erin.
Frank contends with public outcry to defund the NYPD School Safety Division, after a physical altercation between a school officer and a student goes viral; Danny and Baez help a father track down his missing ex-wife and daughter.
Erin's nephew, police officer Joe Hill, becomes aware of witness tampering in a trial; Baez forces Danny to help her find the killer of her favorite TV personality; Eddie questions her decision to become a police sergeant.
Frank contends with a potentially dirty cop within his ranks; Eddie and Badillo track down the culprits behind the theft of valuable, rare works from a celebrated bookstore; Erin snoops into the background of a new woman in Anthony's life.
Frank is at odds with his friend Archbishop Kearns when he says the NYPD arrested the wrong man for a murder; Eddie tries to get justice for a sexual assault survivor; Jamie and his nephew, Joe Hill, butt heads over fair police practices.
Danny pursues a con artist pretending to be the legendary singer Jimmy Buffett; Frank investigates an impressive police captain who is using her badge to get free wares from local stores.
An illegal drug shipment arriving in New York City must be found before the narcotics flood the streets; Jamie helps a neighbor handle a gambling debt; Frank receives pushback from Mayor Chase over his handling of a brawl.
Frank enlists the help of an old friend, Sloane Thompson, to investigate a cyber-attack on the NYPD that forces Danny and Baez to release an evasive suspect. Also, Baez questions her place within the NYPD; Eddie is torn over a workplace dilemma; and Jamie wrestles with a family secret.
Danny partners with Anthony to solve a double homicide when Anthony's shady cousin proves to have gang ties to the crime; the boundary between Eddie and Jamie's work and personal relationship becomes strained.
Danny and Baez's attempts to find who assaulted a shop owner are hindered by the community's refusal to cooperate; Erin's suspicions about her boss rise; Gormley, Garrett and Baker are threatened by a new staff member.
Frank causes family tension when he assigns Jamie to guard Danny after a hit is put on him; Frank tries to stop his grandson from seeking revenge after he’s attacked; Eddie gets a hostile new partner.
Jamie and Eddie experience marital tension when Eddie allows her newly released ex-convict father to live with them; Danny and Baez go out of their way to help a desperate man find his missing sister.
Jamie faces backlash from fellow officers when he partners with Erin and Anthony to investigate an underground bar the NYPD and FDNY use to hide their criminal indiscretions; Eddie's partner considers leaving the force.
Frank must decide between remaining police commissioner and pursuing a new professional chapter when his old friend presents him with an exciting job offer. Danny and Baez investigate the murder of a restaurant delivery man.
Tension escalates between Frank and Mayor Chase after Frank makes a public arrest that goes viral. Danny and Baez investigate a gang attack that takes an unexpected turn. Jamie worries when Eddie lies to him about where she's going in the evenings.
Danny consults a psychic to solve the murder of a young boy; Frank is at odds with the mayor over how best to protect the city from an uptick in crime following a high-profile shooting; Erin investigates a decades-old case.
