Virginia's cousin Delilah, who struggles to make ends meet, pays a visit to the Chance family unannounced, determined to claim her share of Maw Maw's - whom she thinks died years ago - estate. Further tension builds when Delilah admits she still has a crush on Burt. Meanwhile, Jimmy babysits Maw Maw and panics when she takes off on Sabrina's moped.
When Sabrina points out to Jimmy just how many germs are lurking around his house, the Chance family becomes obsessed with cleanliness. Finding it impossible to keep Maw Maw clean, they move her to the backyard greenhouse, but after watching some old family movies, they discover a surprising secret that has kept them healthy all these years.
Jimmy hasn't had any time to socialize or make friends since Hope was born, so when he meets another single dad at the grocery store, he immediately sets up a play date. But when Jimmy finds out that Virginia is his new friend's housekeeper, Virginia insists that Jimmy cancel the outing. In an effort to keep the peace, Jimmy and his friend arrange a dinner at the Chance house.
Instead of sleeping in and ordering pizza, per his normal Thanksgiving custom, Jimmy invites Hope's other grandparents, Dale and Margine, to join the Chances for a more traditional holiday dinner. The Chances soon realize that the apple doesn't fall far from the tree when Dale and Margine kidnap Hope, and it's up to them to get her back.