Danger Mouse travels to the United States where he teams up with a Texan to defeat Greenback, who has shrunk and stolen the world's greatest buildings.

Danger Mouse is sent to the Indian Ocean to investigate several ship sinkings caused by ghost-like buses that vanish.

Greenback is determined to steal plans that Danger Mouse and Penfold are transporting from Australia to London.

Danger Mouse is captured by Greenback when Greenback threatens to destroy all the world's signposts, and is subjected to a brain picker to remove all his thoughts.

Greenback shrinks himself and enters Colonel K's body to learn all of the Colonel's secrets.