The Python Hunters perform a necropsy on a Burmese python killed by cold weather to see whether or not it was a healthy predator. Then, the hunters head to the edge of a sawgrass marsh to explore through knee-deep waters in search of pythons. National Geographic joins the team as they trek through mud and water hoping to find this magnificent snake.

As a cold front hits the state of Florida, the frigid temperatures kill thousands of animals of all species. The Python Hunters head out braving alligators, venomous snakes and the relentless cold to determine how the weather has affected the population of Burmese Pythons.

The Python Hunters tackle the debate over how the Burmese pythons came to be established in the Everglades. National Geographic rides along with these expert hunters as they uncover the mystery behind how these creatures came to roam the land.