When Donnie finds himself in a compromising situation, he calls Pierce for help. As the evidence begins to stack against Donnie, Pierce and Moretti struggle with their own fears and doubts, as they work to solve the case. During the chaos, Pierce must deal with his father after he assaults someone at the assisted living facility.
Donnie and Moretti are caught in the crossfire when a sniper shoots up the lobby of the Federal Building. When Pierce determines that the shooter is afraid of Extreme Low Frequency radio waves, he and Moretti take a trip to the Quiet Zone in Virginia, where they think the shooter is hiding out. Meanwhile, an alluring woman named Shelby Buchanan courts Donnie to run for political office.
After a missing FBI agent turns up dead, Pierce is forced to face the one case he was never able to solve. When they discover that the killer is still out there, Pierce agrees to help Moretti, against the wishes of his therapist, Dr. Rosenthal, who believes it will only exacerbate Pierce’s condition.
After Pierce witnesses a gallery owner die during a seizure caused by a video installation, he convinces Moretti that it was actually a murder. Their search for the killer puts them in the middle of a brazen art heist. As Pierce works on the case, he is forced to re-examine his relationship with Natalie.
When an infant is reported stolen, Moretti hunts down the kidnapper and makes a very bizarre discovery. As Pierce and Moretti investigate a related murder, they find that there might be another child out there who needs their help. Meanwhile, Donnie and Moretti discuss their future together when Donnie looks into buying a house in the suburbs.