Samantha and Darrin are in Mexico City where Darrin is working on a new account for McMann and Tate. Endora puts a spell on him that makes him disappear when he speaks Spanish. Samantha gets her mother back who has the nerve to reverse the spell, this time, making Darrin disappear when he speaks English! Samantha helps him out when he delivers an excellent speech to Spanish and American patrons.
Maurice gives Darrin a magic lighter, which Darrin doesn't accept. Maurice turns Darrin into a donkey because of his ingratitude. Samantha tries to find her father and finds him in Paris. She returns to see that Darrin the donkey has been taken to an animal shelter. Darrin is released and Maurice back tracks everything that he did to turn Darrin back to a human.
The Witches Council takes away Samantha's powers when she refuses to break up with Darrin. Uncle Arthur and Serena help out Samantha and, as a result, loses their powers as well. After a hellacious day in the mortal working world, Serena and Uncle Arthur decide that they are better off with their powers. Samantha goes to the Witches Council and tells them they are in the wrong for their ignorance. Then Samantha, Serena, and Uncle Arthur get their powers back.
Phyllis wants Tabitha to spend a weekend with her and Frank, but doesn't count on Samantha and Endora to be there also. They all start fighting and arguing until Tabitha turns herself into a cookie. Samantha convinces her daughter that she is not the cause of all of their arguments and wants her to turn back into a human.
Serena decides to do the same thing that Samantha did and tries to find a mortal to date. She finds Franklin Blodgett through a computer dating service, but like all TV Land computer dating agencies, the matches always turn out to be bad. This proves this fact when Franklin insults Serena's magic when they are about to be engaged.
Phyllis breaks bad on Samantha's family, and Serena shuts her up by turning her into a cat! Miss Parsons finds Phyllis as a cat and decides to keep her. Meanwhile, Frank is looking for Phyllis and Samantha finds her at Miss Parsons' house with a whole bunch of other cats she has collected! She then finds cat Phyllis and gets Serena to change her back to a human.
Samantha is speaking in rhymes, which turns out to be a bad thing when Darrin is entertaining a client who has been using jingles for years and is tired of them. Larry gets tired of Samantha rhyming and wants her to quit it. Dr. Bombay comes by and gets Samantha to stop rhyming. She then explains to the client that she spoke in rhymes to prove how annoying they can be.
Endora creates a toy called the Fuzz, a toy that has the power to charm people. Darrin presents this idea to Larry and the Fuzz charms Darrin to the tune of a million dollars. Samantha is worried about Darrin when he tells her that he will finally give her and Tabitha everything they could possibly want. Endora removes the spell and Samantha tells Darrin that as long as she and Tabitha love Darrin, that is worth a lot more than money.
The minute Clio flies the coop, Serena comes back. The Stephens and Serena find the monkey Clio in the hands of a little boy, an organgrinder, and the police! Serena changes Clio back and Samantha comes up with a stellar idea for the Clio Vanita wine account when Larry meets the organgrinder who kept Clio company as a monkey.
Samantha wants to keep a willow tree in her yard and decides to treat it. She calls Dr. Bombay to make her tree weep, but Samantha gets caught in the spell and each time the wind blows, she starts crying. When Larry hears her cry, he thinks that she and Darrin are having a fight and comes over to comfort her, but not before Dr. Bombay comes by to give her an antidote to make her laugh. When Larry comes by, Samantha starts laughing and laughing, and Larry starts laughing too. Then Darrin comes in to find Samantha and Larry laughing for no apparent reason. Then Dr. Bombay comes by with another antidote to make everything and everyone normal again.
Tabitha goes to pre-school for the first time and meets Amy, a classmate. When the teacher groups the children in animal groups, Amy gets chosen to be a toad in the toad group, but she wants to be in a butterfly group. Tabitha misunderstands her request and actually turns her into a butterfly! Samantha, who has been watching the whole thing through the window, chases Amy the butterfly all around the city and catches her so Tabitha can change her back.
Samantha gets involved in a fight against tearing down a neighborhood park for a supermarket. The bad news is that the park is owned by Darrin's new client, Mr. Mossler, and because of her involvement, Darrin ends up losing his job. Samantha saves the day when she brings one of the statues in the park to life to convince Mossler to stop with the construction.
Mrs. Stephens drops in unexpectantly, and insists Samantha enter a slogan contest to win a trip to Tahiti. And she wins! Of course, Larry Tate's none to happy as it turns out to be one of their biggest clients. The typical Stephen's fight occurs. Darrin's furious! He thinks Samantha used witchcraft. Darrin heads to the neighborhood bar, gets drunk, and tells the he's married to a witch. Darrin comes around when Samantha's slogan is rejected after all.
Serena is involved again. This time, Drarin takes her to the honeymoon spot where he and Samantha went. Samantha is at a Witches Council meeting and doesn't know what is going on. Darrin gets intimate with Serena, thinking that she is Samantha, and she tells him to back off. Then Tabitha is called to solve the puzzle.
Once upon a time, Endora made a deal with another witch Carlotta that Samantha will marry her son Juke, but Samantha hasn't lived up to her part of the deal. Now Carlotta and Juke are back and Carlotta will stop at nothing to give Juke what he wants. She makes Darrin disappear and never brings him back until Samantha agrees to marry Juke. Samantha tells Juke to finally stand up to his mother and tell her off.
Endora gets Tabitha to play beautifully on the piano, and Darrin dares Samantha to learn how to play the mortal way. The Piano teacher hears Tabitha play and invites a famous conducter to see her play. Without magic, Tabitha does a poor job and the conductor is stunned. Samantha then finds a real prodigy for the conductor, and wins the bet with Darrin.
Because of Serena's foolishness, Samantha is sent back in time by a jelaous witch named Brunhilda, who happened to be Serena's boyfriend's wife. In 1868 New Orleans, Samantha is taken in by a maid named Aunt Jenny, and her owner, Rance Butler, falls for her. Now it is up to Darrin to get her back from the Southern gentleman.