With Cisneros fleeing, and Diego sick with cholera, Julio and Alicia are free to leave the hotel once and for all and start living a life together that until now has been denied. But the dying Diego makes Alicia a proposal that can cause everything to change ... And do it forever. The disease is not Diego's only problem. Cisneros has escaped and is cornered by the police, but he will not hesitate to try to take his revenge against his enemy in any way. Meanwhile, Bethlehem meets again with Bazán to prevent him from discovering his attempt to kill Andres. The reunion between the two will have unexpected and definitive consequences. On the other hand, Diego's disease has infected more hotel workers. Angela fears an epidemic and uses her new position to try to convince Mrs. Teresa and Alfredo that it is best to close the hotel. Refusals to listen to the advice of the governor will endanger not only the sick, but the entire Grand Hotel.
Inspector Ayala has no choice but to arrest Alicia after finding Diego wounded alongside her holding a gun. Maite and Julio try to prove that Alicia was just part of a trap.
The drama intensifies around the Grand Hotel as Julio and Diego have a dramatic showdown. A clash which has potentially life-changing consequences.
Belén is back from the dead and a recently resurrected and naive Andrés welcomes her with open arms. While the hotel seems to be filled with ghosts, we finally learn where Alicia is trapped.
After being accused of murder, Andrés' future is finally decided. Meanwhile, Alfredo uncovers Father Grau's shocking secret.
Andrés ponders his fate after being accused of murdering Belén. However, Julio, Maite and Alicia attempt to come to his rescue, as does his mother, Angela.
Andrés is arrested for the murder of Belén, while an old flame of Javier's threatens to derail his and Laura's post-wedding bliss.
Alicia and Julio are about to unravel the mysteries surrounding Adrián Vera. After Andrés' confession, he got house arrest.
Andrés wakes up covered with blood and Belén has vanished. During an auction, Alicia receives another clue regarding Diego's past.
The Grand Hotel welcomes royal guests, and Alfredo takes the chance to get back his noble title. Andrés and Camilla finally split up thanks to Belén constant mischief.
Javier weds heiress Laura Montenegro unaware of her secret. Alicia's abductor returns to the hotel to blackmail Diego.
Diego has sold the hotel to Celia Velledur. Alicia and Julio look for the car used to kidnap her. Ayala is investigating on the disappearance of Celia, new owner of the hotel.
Alicia returns safely to the hotel but she is amnesic. Diego now single owner of the hotel is considering to sell it. Sofía has recurring nightmares about her past. Alaya tries to frame Alicia's abductors.
In the aftermath of the explosion, Alicia is abducted. The hotel, turned into a makeshift hospital, struggles to cope with numerous injured.
Don Diego's illness presents Alicia and Julio with an unmissable opportunity to live the life they have so far been denied. But can they seize it?
Alicia and Julio finally track down Don Carlos' killer. Dona Teresa has a change of heart regarding Andres' future. But her proposal comes with a price.
Julio and Alicia discover the gold knife killer is willing to do anything to keep his identity a secret. Angela's younger sister shows up at the hotel.
Alicia and Julio's trip to the nunnery leads them to uncover Angela's secret. Plus, Sofia finds herself arrested for murder.
Magician Houdini pays the hotel a visit and offers Julio a new lead into Don Carlos murder. Former maitre Benjamin makes a surprising return to the hotel.
As a member of the Alarcon family learns of Julio and Alicia's affair, Julio finds himself blackmailed into another dangerous scheme.
As Alfredo seeks an annulment to his marriage to Sofia, Dona Teresa seizes a chance to win her hotel back.
A masked ball brings drama and big danger to the hotel as Alfredo's old flame Beatriz shows up and Andres finds himself cornered by a potential killer.
