Dr Pixie comes face to face with three huge hernias, and Dr Christian meets Malissa Jones, who made headlines in 2008, for being the world's first teenager to undergo a gastric band operation.
The second programme meets a husband and wife couple with a combined weight of 52 stone, and a 21-year-old Mum whose life is maligned by her enormous J cup breasts.
In the first of the series, the doctors see some jaw-dropping sights, including Glenn, whose stomach oedema literally touches the floor, and successful slimmer Julia, whose new slim frame is draped in excess skin.