Jackson revisits clients from the first four seasons of the show to see how they and their cats are doing, and also checks back on one of his toughest cases.
A shelter cat dubbed "Crazy Daisy" flies into rages and suffers from self-inflicted wounds; she-devil Gizmo's violent ways cause stress for a married couple who want to start a family.
A long friendship between three women is put at risk by the evil behavior of one's cat; a bad Bengal cat threatens to get her owner kicked out of her parents' home.
A man invites his girlfriend and her foul-tempered feline into his home; two cats that refuse to use a litter box threaten to doom a couple's five-year relationship.
A deaf and blind cat stops using its litter box and becomes hostile toward its owners and a new kitten; a couple puts their family plans on hold due to violent feuding between their dog and cat.