Jimmy shows off some Bad Signs sent in by viewers, gets life advice from Leslie Jones, speaks with X González about March for Our Lives and enjoys a performance by Weezer.
Actor Andrew Garfield; singer-songwriter Sara Bareilles; actress Renée Elise Goldsberry; actress Paula Pell; actress Busy Philipps;Thomas Rhett performs.
Jimmy takes suggestions from the audience in a new Audience Suggestion Box, then chats with Rami Malek and Bridget Everett before enjoying stand-up from comedian Jesus Trejo.
Singer/songwriter Mariah Carey (Mariah Carey's Magical Christmas Special (2020)); actor Andrew Rannells ("The Stand In", "Big Mouth", "Black Monday"); Jose Feliciano performs;
Actors Keanu Reeves and Alex Winter ("Bill and Ted Face the Music"); Gov. Andrew Cuoco (D-N.Y.); actor Joe Manganiello ("Archenemy"); The Smashing Pumpkins perform;
Actress Melissa McCarthy ("Superintelligence"); the original cast of "Saved By the Bell"; Sheryl Crow covers Tom Petty's "You Don't Know How It Feels".
Actor Dan Levy ("Happiest Season" and "Schitt's Creek"); actor/author Michael J. Fox (memoir, "No Time Like the Future: An Optimist Considers Mortality"); Julia Michaels performs.
Actress Kaley Cuoco (The Flight Attendant (2020) and Harley Quinn (2019)); professional soccer player/author Megan Rapinoe (book, "One Life"); 21 Savage and Metro Boomin perform.
Actress America Ferrera ("Every Vote Counts"); YouTube personality David Dobrik; professional baseball player Corey Seager (Los Angeles Dodgers); Brothers Osborne perform.
Actor Anthony Mackie ("The Falcon and the Winter Soldier"); actress Lily James ("Rebecca"); Black Thought performs with Portugal. The Man and The Last Artful Dodgr.
Actor Jim Parsons (The Boys in the Band (2020), Hollywood (2020), and Young Sheldon (2017)); journalist Shepard Smith (The News with Shepard Smith (2020)); BTS perform;
Jimmy sits down with MSNBC correspondent Joy Reid and NAACP President Derrick Johnson to discuss the Breonna Taylor case and welcomes musical guest Anitta, performing "Me Gusta" featuring Cardi B and Myke Towers.