When Brian’s closest relationships implode due to his inability to cut ties with Eddie Morra, he goes rogue from the FBI to free himself from the senator’s control. In Russia, he searches for Piper, Morra’s former associate turned adversary, and her alternative NZT vaccine. Also, Rebecca comes closer to discovering Brian’s connection to NZT and Senator Morra.
When Sands, Senator Morra’s deadly representative, enlists Brian’s help to eliminate an immediate threat he needs to keep secret from the politician, Brian learns Sands’ dangerous and shocking past. Also, Brian’s sister, Rachel, scrambles to cover up his abrupt side mission with Sands when the FBI can’t reach him regarding a new case.
After a list with the real identities of undercover bureau operatives leaks, Brian develops a personal connection with FBI Agent Lucy Church, a tenacious rule-breaker, when he helps her finish a field case before she's exposed. Also, Sands makes a surprising move to end Rebecca's investigation into Senator Morra.
Brian embarks on his first FBI field assignment when he travels to Quantico to lend his skills to the bureau unit that catches serial killers. However, the trip takes a negative turn when Brian realizes the man he's working with may have put away an innocent person in the career-making case that made him a renowned profiler. Also, Brian tries to stay one step ahead of Rebecca as she comes closer to discovering Senator Morra's connection to NZT.
When an assassin makes an attempt on Senator Edward Morra's life, Brian is ordered to sabotage the FBI's investigation into it in order to prevent exposing the Senator's connection to NZT. As Brian and Morra's fates become further intertwined, Brian is faced with how far he's willing to go to protect the politician.