Reeling from a personal loss, Pope Pius XIII makes an impulsive decision to visit Africa, meeting a revered missionary who stirs mixed feelings inside him.
Dussollier blames himself after a tragedy and returns to Honduras. With Lenny's supporters dwindling, he questions whether his papacy is coming to an end.
Believing that the only way to end Lenny's papacy is to involve him in a scandal, Cardinal Secretary of State Voiello blackmails Ester to seduce the pontiff.
After his inaugural speech makes it clear that he will not be manipulated, Lenny makes enemies within the Vatican. However, he gains one ardent follower.