When Miss Piggy suffers a scandalous wardrobe malfunction, the network is outraged, and Piggy is forced to question everything she stands for, but Kermit and the gang rally together and come to her defense. Meanwhile, Gonzo misses his ex-girlfriend Camilla, so Pepe and Rizzo decide to throw a house party to cheer him up.
The whole crew just returned from hiatus, and everyone is rested, recharged and ready to get back to work. But when a new branding guru comes in to revamp "Up Late," the gang rallies together and realizes that they don't need gimmicks and hijinks; they just need each other and a couple of familiar tunes to get them back on track.
The gang is preparing for the annual “Up Late” live Christmas special with, special guest Mindy Kaling. Animal is in charge of tinsel, Sweetums hangs the lights, Sam Eagle strategically places the mistletoe – everything is in order. Or so it seems. Meanwhile, Miss Piggy offers relationship advice to Fozzie, which forces her to reevaluate her relationship with Kermit. Yolanda rigs the Secret Santa gift exchange, and Echosmith performs at the crew’s Christmas party.
Scooter books his long time TV crush, Chelsea Handler, who really heats things up both on 'Up Late' and in Scooter's personal life. Meanwhile, Fozzie wants to take it to the next level with Becky but when Kermit and Denise go on a double date with them, Kermit discovers that Becky might have a few skeletons in her closet.
Fozzie takes things a little too far when Kermit offers him advice and Nick Offerman steps in to help the gang. Meanwhile, Christina Applegate guests on “Up Late,” and brings Miss Piggy a sweet surprise that doesn't go over well and Pepe, Rizzo and Liam Hemsworth try to help Gonzo out with his online dating situation.