During surgery to resolve an HIV-positive woman's post-partum complications, Diane accidentally cuts herself and is exposed to the virus; problems arise between Jack and Lisa when he discovers that she's been seeing Robert; a homeless man takes shelter in the hospital's main entrance; an unidentified man is hit by a train after trying to save a child; Jack takes up golf in the hospital.
Kate discovers that a patient is using Viagra to cheat on his wife; Jack gives a blood transfusion even though it's against the patient's Jehovah's Witness religion; a musician fears his creativity may be stifled by the medicine Aaron prescribes for his bipolar disorder; Joe's son drives the staff crazy as he roams the hospital behaving exactly like his father.
The hospital prepares for the Doctor of the Year party, and several old friends drop by. Watters goes into a virus-induced coma and gets some words of wisdom from Alan Birch. Camille Shutt returns for the party and Aaron discovers he still has feeling for her. Dr. Nyland returns to the hospital and reveals that he has really changed his life. Geiger also visits the hospital.