Mem and Zen take the Noobs to space for the New Virus Warrior Convention and Recruiters Awards where they are not taken seriously and spend the time in their hotel room instead. Meanwhile at the Awards Ceremony, Count Venamus is set on spreading the virus to all the new recruits leaving only the Noobs uninfected to battle the virus.
When Tyler and Shope's guinea pig escapes from home ec class Kevin has to become a guinea pig to sit in while Tyler searches for the real one. Tyler and Roach then discover a virus that recently landed only to find the guinea pig has eaten several of them. Now they must conquer the virus beats and get the guinea pig back in its cage before the end of class.
During rehearsal for the school play where Roach plays a rocket, his battleball becomes activated by his love for the drama coach making him shoot off like a real rocket. Fearful that he will be mistaken for a real missile and shot down the Noobs must find a way to rescue him and bring him back down to Earth.
The Noobs turn to Mem and Zen to help them prepare for the upcoming school dance where a fire virus turns students into fire breathing dragons. In an effort to get closer to Amy, Tyler's plan to save her in his Supernoobs costume backfires when she falls for the super hero version of himself instead.
Shope's parents are concerned about her performance in school and feel that the boys are bad influence. The Noobs sneak into the Galacticus cloaking room where the energy is transferred to Shope, making her invisible instead of the Galacticus. The boys have to keep Shope out of trouble until Mem and Zen can make her visible again.
Nervous that the virus could attack at any minute Kevin insists on wearing his battleball in school when it malfunctions and he gets stuck as a dog. Upon getting caught by the dog catcher and thrown in the pound the virus begins to infect the stray animals. The Noobs must find a way to free him from the pound before he is stuck that way forever while battling the Virus.
Mem and Zen realize their mistake in picking the Noobs and want to take the battleballs back. In order to save themselves the Noobs must go to space to plead their case to the Benevolent Alliance and keep their battleballs. There they are tested individually and judged on their abilities to fight the virus.